Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Ligand

BDBM259596

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

0.302±n/a nM

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Name:

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Synonyms:

Type:

Enzyme

Mol. Mass.:

24581.05

Organism:

Homo sapiens (Human)

Description:

aa 946-1162

Residue:

217

Sequence:

LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKL
WERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENS
SKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSV
TGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG

BDBM259596

n/a

Name

BDBM259596

Synonyms:

US9505749, 109

Type

Small organic molecule

Emp. Form.

C24H24N4O3S

Mol. Mass.

448.537

SMILES

O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)Oc1cccc(c1)C#N |r,wU:17.18,wD:20.25,(2.67,5.39,;1.33,4.62,;,5.39,;-1.33,4.62,;-2.67,5.39,;-4,4.62,;-4,3.08,;-5.33,2.31,;-5.33,.77,;-6.67,,;-8,.77,;-8,2.31,;-6.67,3.08,;-6.67,4.62,;-8,5.39,;-5.33,5.39,;1.33,3.08,;2.67,2.31,;4,3.08,;5.33,2.31,;5.33,.77,;4,,;2.67,.77,;6.67,,;6.67,-1.54,;8,-2.31,;8,-3.85,;6.67,-4.62,;5.33,-3.85,;5.33,-2.31,;4,-4.62,;2.67,-5.39,)|

Structure