Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Ligand | BDBM259600 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
IC50 | 0.294±n/a nM | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Synonyms: | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 24581.05 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 946-1162 | ||
Residue: | 217 | ||
Sequence: |
| ||
BDBM259600 | |||
n/a | |||
Name | BDBM259600 | ||
Synonyms: | US9505749, 113 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H23ClN4O3S | ||
Mol. Mass. | 482.982 | ||
SMILES | Clc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCSc2nc3ccccc3c(=O)[nH]2)cc1C#N |r,wU:9.12,wD:6.5,(6.67,-5.77,;6.67,-4.24,;8,-3.47,;8,-1.93,;6.67,-1.16,;6.67,.38,;5.33,1.15,;5.33,2.69,;4,3.46,;2.67,2.69,;2.67,1.15,;4,.38,;1.33,3.46,;1.33,5,;2.67,5.77,;,5.77,;-1.33,5,;-2.67,5.77,;-4,5,;-4,3.46,;-5.33,2.69,;-5.33,1.15,;-6.67,.38,;-8,1.15,;-8,2.69,;-6.67,3.46,;-6.67,5,;-8,5.77,;-5.33,5.77,;5.33,-1.93,;5.33,-3.47,;4,-4.24,;2.67,-5.01,)| | ||
Structure |