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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Poly [ADP-ribose] polymerase 2 | ||
| Ligand | BDBM259597 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical Assay | ||
| IC50 | 1440±n/a nM | ||
| Citation |  Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Poly [ADP-ribose] polymerase 2 | |||
| Name: | Poly [ADP-ribose] polymerase 2 | ||
| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 66225.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9UGN5 | ||
| Residue: | 583 | ||
| Sequence: |
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| BDBM259597 | |||
| n/a | |||
| Name | BDBM259597 | ||
| Synonyms: | US9505749, 110 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27N5O3S | ||
| Mol. Mass. | 489.589 | ||
| SMILES | O=C(CCCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)c1nnc(o1)-c1ccccc1 |r,wU:18.19,wD:21.26,(-2.08,.92,;-2.08,-.62,;-3.42,-1.39,;-4.75,-.62,;-4.75,.92,;-6.08,1.69,;-7.42,.92,;-7.42,-.62,;-8.75,-1.39,;-8.75,-2.93,;-10.08,-3.7,;-11.42,-2.93,;-11.42,-1.39,;-10.08,-.62,;-10.08,.92,;-11.42,1.69,;-8.75,1.69,;-.75,-1.39,;.58,-.62,;.58,.92,;1.92,1.69,;3.25,.92,;3.25,-.62,;1.92,-1.39,;4.59,1.69,;4.59,3.23,;6.05,3.7,;6.96,2.46,;6.05,1.21,;8.44,2.06,;8.84,.57,;10.33,.17,;11.42,1.26,;11.02,2.75,;9.53,3.15,)| | ||
| Structure | 
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