| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [4-503,T204D] |
|---|
| Ligand | BDBM412758 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assays |
|---|
| IC50 | 4.70±n/a nM |
|---|
| Citation |  Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent US10399987 Publication Date 9/3/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-1 [4-503,T204D] |
|---|
| Name: | TGF-beta receptor type-1 [4-503,T204D] |
|---|
| Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 T204D | TGFBR1 | TGFR-1 T204D | TGFR1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55650.84 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36897 T204D |
|---|
| Residue: | 500 |
|---|
| Sequence: | AVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTD
KVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGP
VELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYD
MTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF
REAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMI
KLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATD
TIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHED
YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARL
TALRIKKTLSQLSQQEGIKM
|
|
|
|---|
| BDBM412758 |
|---|
| n/a |
|---|
| Name | BDBM412758 |
|---|
| Synonyms: | N-(4-((2-(5-(trifluoromethyl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyridin-2-yl)acetamide | US10399987, Example 23 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14F3N7O |
|---|
| Mol. Mass. | 413.356 |
|---|
| SMILES | CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(cn2)C(F)(F)F)ccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
