| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 [181-417] |
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| Ligand | BDBM413121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 3.98±n/a nM |
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| Citation |  Brown, JW; Davis, M; Ivetac, A; Jones, B; Kiryanov, AA; Kuehler, J; Lanier, M; Miura, J; Murphy, S; Wang, X 6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD US Patent US10407409 Publication Date 9/10/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Egl nine homolog 1 [181-417] |
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| Name: | Egl nine homolog 1 [181-417] |
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| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417) |
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| Type: | Enzyme |
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| Mol. Mass.: | 26555.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 181-417 |
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| Residue: | 237 |
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| Sequence: | PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
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| BDBM413121 |
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| n/a |
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| Name | BDBM413121 |
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| Synonyms: | 4-(1-(5-(3-(dimethylamino)azetidine-1-carbonyl)pyridin-2-yl)-5-hydroxy-1H-pyrazol-4-yl)-2-fluoro-3-methylbenzonitrile | US10407409, Example 321 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21FN6O2 |
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| Mol. Mass. | 420.4395 |
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| SMILES | CN(C)C1CN(C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |
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| Structure | 
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