Reaction Details |
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Target | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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Ligand | BDBM415303 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Assay |
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IC50 | 3.55±n/a nM |
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Citation | Graham, K; Klar, U; Briem, H; Hitchcock, M; Bärfacker, L; Eis, K; Schulze, V; Siemeister, G; Bone, W; Schröder, J; Holton, S; Lienau, P; Tempel, R; Sonnenschein, H; Bálint, J; Graubaum, H 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones US Patent US10428044 Publication Date 10/1/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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Name: | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
Synonyms: | BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1 |
Type: | PROTEIN |
Mol. Mass.: | 122372.31 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1510603 |
Residue: | 1085 |
Sequence: | MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
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BDBM415303 |
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n/a |
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Name | BDBM415303 |
Synonyms: | Intermediate 1-2-69 | US10428044, Example 410 |
Type | Small organic molecule |
Emp. Form. | C24H29N3O3S |
Mol. Mass. | 439.57 |
SMILES | COCCOc1cnccc1CNC1=C(C(=S)Nc2ccccc2)C(=O)CC(C)(C)C1 |c:14| |
Structure |
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