| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
|---|
| Ligand | BDBM415357 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | 4.49±n/a nM |
|---|
| Citation |  Graham, K; Klar, U; Briem, H; Hitchcock, M; Bärfacker, L; Eis, K; Schulze, V; Siemeister, G; Bone, W; Schröder, J; Holton, S; Lienau, P; Tempel, R; Sonnenschein, H; Bálint, J; Graubaum, H 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones US Patent US10428044 Publication Date 10/1/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitotic checkpoint serine/threonine-protein kinase BUB1 |
|---|
| Name: | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
|---|
| Synonyms: | BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 122372.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1510603 |
|---|
| Residue: | 1085 |
|---|
| Sequence: | MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
|
|
|
|---|
| BDBM415357 |
|---|
| n/a |
|---|
| Name | BDBM415357 |
|---|
| Synonyms: | Preparation of N-{4-[4′-oxo-3′-(phenylamino)-1′,4′,5′,7′-tetrahydrospiro[cyclopropane-1,6′-indol]-2′-yl]pyridin-2-yl}-1,3-oxazole-4-carboxamide | US10428044, Example 470 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H21N5O3 |
|---|
| Mol. Mass. | 439.4659 |
|---|
| SMILES | O=C(Nc1cc(ccn1)-c1[nH]c2CC3(CC3)CC(=O)c2c1Nc1ccccc1)c1cocn1 |
|---|
| Structure | 
|
|---|
Search and Browse
