| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM254252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Ca2+ flux assay |
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| pH | 7.4±n/a |
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| IC50 | 2.00±n/a nM |
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| Comments | extracted |
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| Citation |  Alcazar Vaca, MJ; Allison, BD; Andres Gil, JI; Chrovian, CC; Coate, HR; De Angelis, M; Deng, X; Dvorak, CA; Gelin, CF; Letavic, MA; Liang, JT; Mani, NS; Rech, JC; Savall, BM; Soyode-Johnson, A; Stenne, BM; Swanson, DM; Wall, JL P2X7 modulators and methods of use US Patent US10112937 Publication Date 10/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM254252 |
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| n/a |
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| Name | BDBM254252 |
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| Synonyms: | US10112937, Example 142 | US10150765, Example 142 | US10703749, Example 142 | US9464084, 142 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2FN5O |
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| Mol. Mass. | 406.241 |
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| SMILES | C[C@@H]1N(CCc2c1nnn2-c1ccccn1)C(=O)c1ccc(F)c(Cl)c1Cl |r| |
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| Structure | 
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