| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
|---|
| Ligand | BDBM419863 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Caliper Mobility Shift Assay |
|---|
| IC50 | <20±n/a nM |
|---|
| Citation |  Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X 2,4-disubstituted pyrimidines as CDK inhibitors US Patent US10464927 Publication Date 11/5/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 4 |
|---|
| Name: | Cyclin-dependent kinase 4 |
|---|
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33731.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11802 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
|
|
|
|---|
| BDBM419863 |
|---|
| n/a |
|---|
| Name | BDBM419863 |
|---|
| Synonyms: | US10464927, Compound I-11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H34FN9 |
|---|
| Mol. Mass. | 515.6283 |
|---|
| SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ncnc4n(C5CCCC5)c(C)cc34)nc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
