Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK3 [512-1124]

Ligand

BDBM387819

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Inhibition Assay

IC50

33.9±n/a nM

Citation

Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Small molecule inhibitors of the JAK family of kinases US Patent US10487083 Publication Date 11/26/2019

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK3 [512-1124]

Name:

Tyrosine-protein kinase JAK3 [512-1124]

Synonyms:

JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN

Type:

Protein

Mol. Mass.:

68951.94

Organism:

Homo sapiens (Human)

Description:

P52333[512-1124]

Residue:

613

Sequence:

TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLE
AASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQL
AYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWV
APECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTE
LALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYAC
QDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQRE
IQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSS
QICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPI
FWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLL
ELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFT
AHPEGKHHSLSFS

BDBM387819

n/a

Name

BDBM387819

Synonyms:

2-((1r,4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10294226, Compound Ex. 2 | US10487083, Example 2 | US10981911, Example 2

Type

Small organic molecule

Emp. Form.

C19H19N7

Mol. Mass.

345.4011

SMILES

N#CC[C@H]1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1 |r,wU:3.2,(5.45,3.94,;3.94,4.26,;2.44,4.58,;1.41,3.44,;1.88,1.97,;.85,.83,;-.65,1.15,;-1.13,2.61,;-.1,3.76,;-1.68,0,;-3.22,.17,;-3.84,-1.24,;-2.7,-2.27,;-2.7,-3.81,;-1.36,-4.58,;-.03,-3.81,;1.43,-4.29,;2.34,-3.04,;1.43,-1.8,;-.03,-2.27,;-1.36,-1.5,;-3.99,1.5,;-5.45,1.97,;-5.45,3.51,;-3.99,3.99,;-3.08,2.74,)|

Structure