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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Non-receptor tyrosine-protein kinase TYK2 [580-1182] | ||
| Ligand | BDBM387824 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 4.80±n/a nM | ||
| Citation |  Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Small molecule inhibitors of the JAK family of kinases US Patent US10487083 Publication Date 11/26/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Non-receptor tyrosine-protein kinase TYK2 [580-1182] | |||
| Name: | Non-receptor tyrosine-protein kinase TYK2 [580-1182] | ||
| Synonyms: | TYK2 | TYK2 (aa 580-1182) | TYK2_HUMAN | ||
| Type: | n/a | ||
| Mol. Mass.: | 68754.63 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29597[580-1182] | ||
| Residue: | 608 | ||
| Sequence: |
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| BDBM387824 | |||
| n/a | |||
| Name | BDBM387824 | ||
| Synonyms: | N-(2-Cyano-2-methylpropyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide | US10294226, Compound Ex. 7 | US10487083, Example 7 | US10981911, Example 22 | US11059823, Example 7 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H27N7O | ||
| Mol. Mass. | 417.5068 | ||
| SMILES | CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C#N |r,wU:23.26,wD:20.22,(-5.09,-2.66,;-5.49,-1.17,;-4,-1.57,;-4.72,.17,;-3.18,.17,;-2.41,1.5,;-3.18,2.83,;-.87,1.5,;-.1,.17,;-.72,-1.24,;.42,-2.27,;.42,-3.81,;1.75,-4.58,;3.09,-3.81,;4.55,-4.29,;5.46,-3.04,;4.55,-1.8,;3.09,-2.27,;1.75,-1.5,;1.43,0,;2.46,1.15,;3.97,.83,;5,1.97,;4.52,3.44,;5.56,4.58,;7.06,4.26,;8.57,3.94,;3.02,3.76,;1.99,2.61,;-7.03,-1.17,;-8.57,-1.17,)| | ||
| Structure | 
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