| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4C |
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| Ligand | BDBM296120 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JMJD2C Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 550±n/a nM |
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| Comments | extracted |
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| Citation |  Boloor, A; Kanouni, T; Stafford, JA; Veal, JM; Wallace, MB Histone demethylase inhibitors US Patent US10112940 Publication Date 10/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4C |
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| Name: | Lysine-specific demethylase 4C |
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| Synonyms: | GASC-1 protein | GASC1 | Gene amplified in squamous cell carcinoma 1 protein | JHDM3C | JMJD2C | JmjC domain-containing histone demethylation protein 3C | Jumonji domain-containing protein 2C | KDM4C | KDM4C_HUMAN | KIAA0780 |
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| Type: | Protein |
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| Mol. Mass.: | 119979.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H3R0 |
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| Residue: | 1056 |
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| Sequence: | MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC
YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE
RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF
GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL
RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID
YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL
QRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAV
KLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSI
SSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLE
PGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEV
LSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAK
CCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAV
AVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTC
AHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVM
AVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGS
NIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGER
KRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
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| BDBM296120 |
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| n/a |
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| Name | BDBM296120 |
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| Synonyms: | 4-[3-[4-(4-hydroxypyrido[3,4-d]pyrimidin- 2-yl)oxy-N-methylanilino]phenyl]-1- methylpiperazin-2-one | US10112940, Example 45 | US10202381, Example 45 | US10208039, Example 45 | US10611763, Example 45 | US10815234, Example 45 | US11535616, Example 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N6O3 |
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| Mol. Mass. | 456.4965 |
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| SMILES | CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCN(C)C(=O)C1 |
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| Structure | 
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