| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SUV39H2 |
|---|
| Ligand | BDBM422898 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Suv 39H2 Assay |
|---|
| IC50 | 3.35±n/a nM |
|---|
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Chakrabarti, A; Rawat, M; Rai, S; Satyanarayana, AV; Duan, Z; Talukdar, A; Ravula, S; Decornez, H Bicyclic compound and use thereof for inhibiting SUV39H2 US Patent US10508109 Publication Date 12/17/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-lysine N-methyltransferase SUV39H2 |
|---|
| Name: | Histone-lysine N-methyltransferase SUV39H2 |
|---|
| Synonyms: | H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46692.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H5I1 |
|---|
| Residue: | 410 |
|---|
| Sequence: | MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
|
|
|
|---|
| BDBM422898 |
|---|
| n/a |
|---|
| Name | BDBM422898 |
|---|
| Synonyms: | N1-(2-(5-chloro-2,4- dimethoxyphenyl)-7- morpholinoimidazo[1,2- a]pyridine-6-yl)ethane-1,2- diamine | US10508109, Example 89 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26ClN5O3 |
|---|
| Mol. Mass. | 431.916 |
|---|
| SMILES | COc1cc(CO)c(cc1Cl)-c1cn2cc(NCCN)c(cc2n1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
