Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 1 [194-712] |
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Ligand | BDBM318825 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Assay |
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IC50 | <100±n/a nM |
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Citation | Chen, X; Lan, R; Jorand-Lebrun, C; Yu, H; Goutopoulos, A Pyridazinone macrocycles as IRAK inhibitors and uses thereof US Patent US10517872 Publication Date 12/31/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 1 [194-712] |
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Name: | Interleukin-1 receptor-associated kinase 1 [194-712] |
Synonyms: | IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 55943.99 |
Organism: | Homo sapiens (Human) |
Description: | aa 194-712 |
Residue: | 519 |
Sequence: | RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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BDBM318825 |
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n/a |
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Name | BDBM318825 |
Synonyms: | US10517872, Compound 2 | US9624246, Compound 2 |
Type | Small organic molecule |
Emp. Form. | C22H20N8O3 |
Mol. Mass. | 444.446 |
SMILES | Cn1cc2NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cnn(CCNC(=O)c2n1)c4)c3 |
Structure |
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