| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM430818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | 3H-SB222200 Binding Competition Assay with Human NK-3 Receptor |
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| Ki | 750±n/a nM |
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| Citation |  Hoveyda, HR; Roy, M; Fraser, GL; Dutheuil, G NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders US Patent US10544150 Publication Date 1/28/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52221.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29371 |
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| Residue: | 465 |
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| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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| BDBM430818 |
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| n/a |
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| Name | BDBM430818 |
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| Synonyms: | (4-fluorophenyl)(3-(2-(4-(4-methylpiperazin-1-yl)phenyl)thiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone | US10544150, Compound 242 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26FN7OS |
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| Mol. Mass. | 503.594 |
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| SMILES | CN1CCN(CC1)c1ccc(cc1)-c1nc(cs1)-c1nnc2CN(CCn12)C(=O)c1ccc(F)cc1 |
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| Structure | 
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