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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase SMYD3 | ||
| Ligand | BDBM432822 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | SMYD3 Biochemical Assay | ||
| IC50 | 0.800±n/a nM | ||
| Citation |  Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent US10577363 Publication Date 3/3/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase SMYD3 | |||
| Name: | Histone-lysine N-methyltransferase SMYD3 | ||
| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 49101.22 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9H7B4-2 | ||
| Residue: | 428 | ||
| Sequence: |
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| BDBM432822 | |||
| n/a | |||
| Name | BDBM432822 | ||
| Synonyms: | N-((1R,3r,5S)-8-((4- aminocyclohexyl)sulfonyl)-8- azabicyclo[3.2.1]octan-3-yl)-5- cyclopropylisoxazole-3-carboxamide | US10577363, Compound 525 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H30N4O4S | ||
| Mol. Mass. | 422.542 | ||
| SMILES | NC1CCC(CC1)S(=O)(=O)N1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)c1cc(on1)C1CC1 |r,wU:16.20,wD:11.11,14.15,THB:7:10:16.17.15:12.13,(9.34,-1.2,;8.01,-.43,;6.67,-1.2,;5.34,-.43,;5.34,1.11,;6.67,1.88,;8.01,1.11,;4.01,1.88,;3.24,3.21,;4.78,3.21,;2.67,1.11,;2.67,-.43,;1.13,-.43,;.57,.55,;1.34,1.88,;.01,1.11,;.01,-.43,;1.34,-1.2,;-1.33,-1.2,;-2.66,-.43,;-2.66,1.11,;-4,-1.2,;-5.46,-.72,;-6.37,-1.97,;-5.46,-3.21,;-4,-2.74,;-7.85,-1.57,;-8.94,-.48,;-9.34,-1.97,)| | ||
| Structure | 
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