| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SMYD3 |
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| Ligand | BDBM432827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SMYD3 Biochemical Assay |
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| IC50 | 0.900±n/a nM |
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| Citation |  Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent US10577363 Publication Date 3/3/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SMYD3 |
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| Name: | Histone-lysine N-methyltransferase SMYD3 |
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| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49101.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H7B4-2 |
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| Residue: | 428 |
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| Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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| BDBM432827 |
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| n/a |
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| Name | BDBM432827 |
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| Synonyms: | 5-cyclopropyl-N-((2S,4S)-2-methyl-1- (((1-phenethylpiperidin-4- yl)methyl)sulfonyl)piperidin-4- yl)isoxazole-3-carboxamide | US10577363, Compound 530 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H38N4O4S |
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| Mol. Mass. | 514.68 |
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| SMILES | C[C@H]1C[C@H](CCN1S(=O)(=O)CC1CCN(CCc2ccccc2)CC1)NC(=O)c1cc(on1)C1CC1 |r| |
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| Structure | 
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