Reaction Details |
| Report a problem with these data |
Target | Histone-lysine N-methyltransferase SMYD3 |
---|
Ligand | BDBM433088 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | SMYD3 Biochemical Assay |
---|
IC50 | 1.85±n/a nM |
---|
Citation | Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent US10577363 Publication Date 3/3/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone-lysine N-methyltransferase SMYD3 |
---|
Name: | Histone-lysine N-methyltransferase SMYD3 |
Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
Type: | Enzyme |
Mol. Mass.: | 49101.22 |
Organism: | Homo sapiens (Human) |
Description: | Q9H7B4-2 |
Residue: | 428 |
Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
|
|
|
BDBM433088 |
---|
n/a |
---|
Name | BDBM433088 |
Synonyms: | 5-cyclopropyl-N-((1R,3r,5S)-8-((4-((2- hydroxyethyl)amino)piperidin-1- yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3- yl)isoxazole-3-carboxamide | US10577363, Compound 792 |
Type | Small organic molecule |
Emp. Form. | C21H33N5O5S |
Mol. Mass. | 467.582 |
SMILES | OCCNC1CCN(CC1)S(=O)(=O)N1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)c1cc(on1)C1CC1 |r,TLB:10:13:16.15:20.19.18| |
Structure |
|