| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 |
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| Ligand | BDBM437694 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Potency |
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| IC50 | 32.8±2.4 nM |
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| Citation |  Wang, Z; Kankanala, J; Pommier, Y Compounds for cancer chemotherapeutic sensitization US Patent US10617706 Publication Date 4/14/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 2 |
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| Name: | Tyrosyl-DNA phosphodiesterase 2 |
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| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40916.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_23510348 |
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| Residue: | 362 |
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| Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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| BDBM437694 |
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| n/a |
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| Name | BDBM437694 |
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| Synonyms: | US10617706, Example 128 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H15ClN4O3 |
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| Mol. Mass. | 442.854 |
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| SMILES | Oc1ccc(cc1)N1C2NC(=O)N(C(=O)C2=Cc2ccc(cc12)C#N)c1ccc(Cl)cc1 |c:17| |
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| Structure | 
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