Reaction Details |
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Target | Cyclin-dependent kinase 5 activator 1 [99-307] |
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Ligand | BDBM7108 |
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Substrate/Competitor | Histone H1 |
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Meas. Tech. | Kinase SPA Assay |
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IC50 | 114±n/a nM |
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Citation | Pevarello, P; Brasca, MG; Amici, R; Orsini, P; Traquandi, G; Corti, L; Piutti, C; Sansonna, P; Villa, M; Pierce, BS; Pulici, M; Giordano, P; Martina, K; Fritzen, EL; Nugent, RA; Casale, E; Cameron, A; Ciomei, M; Roletto, F; Isacchi, A; Fogliatto, G; Pesenti, E; Pastori, W; Marsiglio, A; Leach, KL; Clare, PM; Fiorentini, F; Varasi, M; Vulpetti, A; Warpehoski, MA 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem47:3367-80 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cyclin-dependent kinase 5 activator 1 [99-307] |
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Name: | Cyclin-dependent kinase 5 activator 1 [99-307] |
Synonyms: | CDK5/p25 | Cyclin-Dependent Kinase 5 (CDK5) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 5 |
Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
Type: | Enzyme Subunit |
Mol. Mass.: | 33308.61 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 292 |
Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
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Component 2 |
Name: | Cyclin-dependent kinase 5 activator 1 [99-307] |
Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator | Cyclin-dependent kinase 5 activator 1, p25 | NCK5A | TPKII regulatory subunit | p25 |
Type: | Enzyme Subunit |
Mol. Mass.: | 23250.56 |
Organism: | Homo sapiens (Human) |
Description: | Q15078 aa 99-307 |
Residue: | 209 |
Sequence: | AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEF
LCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGS
DHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINAD
PHYFTQVFSDLKNESGQEDKKRLLLGLDR
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BDBM7108 |
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Histone H1 |
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Name: | Histone H1 |
Synonyms: | n/a |
Type: | Other Protein Type |
Mol. Mass.: | 358.43 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 3 |
Sequence: | |