| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Ligand | BDBM445132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | UCHL1 Biochemical IC50 Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent US10669234 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24819.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_974327 |
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| Residue: | 223 |
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| Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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| BDBM445132 |
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| n/a |
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| Name | BDBM445132 |
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| Synonyms: | (2S,4S)-1-Cyano-4-methoxy-N-methyl-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide | US10669234, Example 71 | US11319287, Example 71 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N3O4S |
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| Mol. Mass. | 417.522 |
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| SMILES | CO[C@H]1C[C@H](N(C1)C(=O)OC(C)(C)C)C(=O)N(C)c1nc(cs1)-c1ccccc1 |r| |
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| Structure | 
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