| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 5 |
|---|
| Ligand | BDBM451298 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Citation |  Tatlock, JH; McAlpine, IJ; Tran-Dube, MB; Rui, EY; Wythes, MJ; Kumpf, RA; McTigue, MA; Patman, R Substituted carbonucleoside derivatives useful as anticancer agents US Patent US10709709 Publication Date 7/14/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein arginine N-methyltransferase 5 |
|---|
| Name: | Protein arginine N-methyltransferase 5 |
|---|
| Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 72679.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14744 |
|---|
| Residue: | 637 |
|---|
| Sequence: | MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
|
|
|
|---|
| BDBM451298 |
|---|
| n/a |
|---|
| Name | BDBM451298 |
|---|
| Synonyms: | US10709709, Example 125 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20BrF2N5O3 |
|---|
| Mol. Mass. | 496.305 |
|---|
| SMILES | Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
