| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 [1-188] |
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| Ligand | BDBM50397778 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogenous Time-Resolved Fluorescence Assay (HTRF1 Assay) |
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| IC50 | 150±n/a nM |
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| Citation |  Bartberger, MD; Gonzalez Buenrostro, A; Beck, HP; Chen, X; Connors, RV; Deignan, J; Duquette, JA; Eksterowicz, J; Fisher, B; Fox, BM; Fu, J; Fu, Z; Gonzalez Lopez De Turiso, F; Gribble, Jr., MW; Gustin, DJ; Heath, JA; Huang, X; Jiao, X; Johnson, MG; Kayser, F; Kopecky, DJ; Lai, S; Li, Y; Li, Z; Liu, J; Low, JD; Lucas, BS; Ma, Z; McGee, LR; McIntosh, J; McMinn, DL; Medina, JC; Mihalic, JT; Olson, SH; Rew, Y; Roveto, PM; Sun, D; Wang, X; Wang, Y; Yan, X; Yu, M; Zhu, J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent US9593129 Publication Date 3/14/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 [1-188] |
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| Name: | E3 ubiquitin-protein ligase Mdm2 [1-188] |
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| Synonyms: | E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 21319.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987[1-188] |
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| Residue: | 188 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
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|
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| BDBM50397778 |
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| n/a |
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| Name | BDBM50397778 |
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| Synonyms: | CHEMBL2177813 | US9593129, Example 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23Cl2NO3 |
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| Mol. Mass. | 432.34 |
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| SMILES | OC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r| |
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| Structure | 
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