| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 [397-806] |
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| Ligand | BDBM350018 |
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| Substrate/Competitor | n/a |
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| IC50 | 3.80±n/a nM |
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| Citation |  Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 3 [397-806] |
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| Name: | Fibroblast growth factor receptor 3 [397-806] |
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| Synonyms: | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45431.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22607[397-806] |
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| Residue: | 410 |
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| Sequence: | RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE
LELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD
KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLD
YSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADF
GLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP
GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS
TDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
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| BDBM350018 |
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| n/a |
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| Name | BDBM350018 |
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| Synonyms: | 6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4- yl)pyrazin-2-yl)-2-(3,5- dimethoxyphenyl)pyridazin- 3(2H)-one 2,2,2- trifluoroacetate salt | US10208024, Example 17 | US10766881, Example 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N7O3 |
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| Mol. Mass. | 445.4738 |
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| SMILES | COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1 |
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| Structure | 
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