| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM280527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Competitive Activity-Based Protein Profiling Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Buzard, DJ; Shaghafi, MB; Cisar, JS; Grice, CA; Jones, TK; Weber, OD Spirocycle compounds and methods of making and using same US Patent US10781211 Publication Date 9/22/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM280527 |
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| n/a |
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| Name | BDBM280527 |
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| Synonyms: | US10030020, Example 72 | US10781211, Example 201 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28F9N3O2 |
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| Mol. Mass. | 561.4836 |
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| SMILES | FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc(cc3N3CCCC3)C(F)(F)F)C2)CC1)C(F)(F)F |
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| Structure | 
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