| Reaction Details |
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 | Report a problem with these data |
| Target | Short transient receptor potential channel 6 |
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| Ligand | BDBM466587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | High Throughput Screening Assay |
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| IC50 | <27.0±n/a nM |
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| Citation |  Bouyssou, T; Gottschling, D; Heine, N; Keenan, LL; Lowe, MD; Razavi, H; Sarko, CR; Surprenant, S; Takahashi, H; Turner, MR; Wu, X Inhibitors of TRPC6 US Patent US10800757 Publication Date 10/13/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Short transient receptor potential channel 6 |
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| Name: | Short transient receptor potential channel 6 |
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| Synonyms: | TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 106326.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107640 |
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| Residue: | 931 |
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| Sequence: | MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE
CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI
LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR
KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL
SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR
PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL
ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA
KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS
FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA
IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI
GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL
NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL
KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS
EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE
EKSQNTEDLAELIRELGEKLSMEPNQEETNR
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| BDBM466587 |
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| n/a |
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| Name | BDBM466587 |
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| Synonyms: | (6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyridinyl-1'-yl)-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone | US10800757, Compound 3 | US10889568, Compound 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N4O3 |
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| Mol. Mass. | 404.4617 |
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| SMILES | COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nc1 |
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| Structure | 
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