Compile Data Set for Download or QSAR

Found 1151 hits with Last Name = 'gottschling' and Initial = 'd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181583 (US9139577, 4.089 | US9139577, 4.108 | US9708274, 4...) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCCC(F)(F)F |r| Show InChI InChI=1S/C24H25F4N5O3S/c1-14-10-17(33-37(35)8-3-9-37)12-19-21(14)22(31-13-30-19)32-18-5-4-16(25)11-20(18)36-15(2)23(34)29-7-6-24(26,27)28/h4-5,10-13,15H,3,6-9H2,1-2H3,(H,29,34)(H,30,31,32)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181584 (US9139577, 4.090 | US9708274, 4.090) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)N[C@H](C)C(F)(F)F |r| Show InChI InChI=1S/C23H22ClF4N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(25)4-5-17(19)32-21-20-16(24)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181585 (US9139577, 4.091 | US9708274, 4.091) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C21H20ClF4N5O3S/c1-11(20(32)27-9-21(24,25)26)34-17-6-12(23)4-5-15(17)30-19-18-14(22)7-13(31-35(2,3)33)8-16(18)28-10-29-19/h4-8,10-11H,9H2,1-3H3,(H,27,32)(H,28,29,30)/t11-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181587 (US9139577, 4.093 | US9708274, 4.093) Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C#N |r| Show InChI InChI=1S/C24H24ClFN6O3S/c1-14(12-27)30-24(33)15(2)35-21-9-16(25)5-6-19(21)31-23-22-18(26)10-17(11-20(22)28-13-29-23)32-36(34)7-3-4-8-36/h5-6,9-11,13-15H,3-4,7-8H2,1-2H3,(H,30,33)(H,28,29,31)/t14-,15+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181588 (US9139577, 4.094 | US9708274, 4.094) Show SMILES C[C@@H](Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F |r| Show InChI InChI=1S/C23H24ClF3N6O3S/c1-12-9-15(33-37(35)7-4-8-37)10-17-19(12)20(29-11-28-17)31-16-5-6-18(24)32-22(16)36-13(2)21(34)30-14(3)23(25,26)27/h5-6,9-11,13-14H,4,7-8H2,1-3H3,(H,30,34)(H,28,29,31)/t13-,14+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181590 (US9139577, 4.096 | US9708274, 4.096) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F |r| Show InChI InChI=1S/C23H22ClF4N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(25)4-5-17(19)32-21-20-16(24)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181591 (US9139577, 4.097 | US9708274, 4.097) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC#N |r| Show InChI InChI=1S/C22H20F2N6O3S/c1-13(22(31)26-6-5-25)33-19-9-14(23)3-4-17(19)29-21-20-16(24)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,6-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181597 (US9139577, 4.103 | US9708274, 4.103) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC#N |r| Show InChI InChI=1S/C23H23FN6O3S/c1-14-10-17(30-34(32)8-3-9-34)12-19-21(14)22(28-13-27-19)29-18-5-4-16(24)11-20(18)33-15(2)23(31)26-7-6-25/h4-5,10-13,15H,3,7-9H2,1-2H3,(H,26,31)(H,27,28,29)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181598 (US9139577, 4.104 | US9708274, 4.104) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F |r| Show InChI InChI=1S/C24H25F4N5O3S/c1-13-9-17(33-37(35)7-4-8-37)11-19-21(13)22(30-12-29-19)32-18-6-5-16(25)10-20(18)36-14(2)23(34)31-15(3)24(26,27)28/h5-6,9-12,14-15H,4,7-8H2,1-3H3,(H,31,34)(H,29,30,32)/t14-,15+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181605 (US9139577, 4.111 | US9708274, 4.111) Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)F |r| Show InChI InChI=1S/C23H24ClF2N5O3S/c1-13-8-16(31-35(33)6-3-7-35)10-18-21(13)22(29-12-28-18)30-17-5-4-15(24)9-19(17)34-14(2)23(32)27-11-20(25)26/h4-5,8-10,12,14,20H,3,6-7,11H2,1-2H3,(H,27,32)(H,28,29,30)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181607 (US9139577, 4.113 | US9708274, 4.113) Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N |r| Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181616 (US9139577, 4.122 | US9708274, 4.122) Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C23H23ClF3N5O3S/c1-13-8-16(32-36(34)6-3-7-36)10-18-20(13)21(30-12-29-18)31-17-5-4-15(24)9-19(17)35-14(2)22(33)28-11-23(25,26)27/h4-5,8-10,12,14H,3,6-7,11H2,1-2H3,(H,28,33)(H,29,30,31)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181618 (US9139577, 4.124 | US9708274, 4.124) Show SMILES C[C@@H](Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C22H22ClF3N6O3S/c1-12-8-14(32-36(34)6-3-7-36)9-16-18(12)19(29-11-28-16)30-15-4-5-17(23)31-21(15)35-13(2)20(33)27-10-22(24,25)26/h4-5,8-9,11,13H,3,6-7,10H2,1-2H3,(H,27,33)(H,28,29,30)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181619 (US9139577, 4.125 | US9708274, 4.125) Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(F)F |r| Show InChI InChI=1S/C24H26ClF2N5O3S/c1-13-9-17(32-36(34)7-4-8-36)11-19-21(13)23(29-12-28-19)31-18-6-5-16(25)10-20(18)35-15(3)24(33)30-14(2)22(26)27/h5-6,9-12,14-15,22H,4,7-8H2,1-3H3,(H,30,33)(H,28,29,31)/t14?,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181625 (US9139577, 4.131 | US9708274, 4.131) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NC(CF)CF |r| Show InChI InChI=1S/C24H26F3N5O3S/c1-14-8-17(32-36(34)6-3-7-36)10-20-22(14)23(29-13-28-20)31-19-5-4-16(27)9-21(19)35-15(2)24(33)30-18(11-25)12-26/h4-5,8-10,13,15,18H,3,6-7,11-12H2,1-2H3,(H,30,33)(H,28,29,31)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181626 (US9139577, 4.132 | US9708274, 4.132) Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C#N |r| Show InChI InChI=1S/C24H25FN6O3S/c1-14-9-18(31-35(33)7-4-8-35)11-20-22(14)23(28-13-27-20)30-19-6-5-17(25)10-21(19)34-16(3)24(32)29-15(2)12-26/h5-6,9-11,13,15-16H,4,7-8H2,1-3H3,(H,29,32)(H,27,28,30)/t15?,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM261870 (US9708274, 4.136) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)N[C@@H](C)C(F)(F)F |r| Show InChI InChI=1S/C24H24F5N5O3S/c1-13(23(35)32-14(2)24(27,28)29)37-20-9-15(25)5-6-18(20)33-22-21-17(26)10-16(11-19(21)30-12-31-22)34-38(36)7-3-4-8-38/h5-6,9-14H,3-4,7-8H2,1-2H3,(H,32,35)(H,30,31,33)/t13-,14+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181631 (US9139577, 4.137 | US9708274, 4.137) Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N |r| Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181633 (US9139577, 4.139 | US9708274, 4.139) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C23H23F4N5O3S/c1-13-8-16(32-36(34)6-3-7-36)10-18-20(13)21(30-12-29-18)31-17-5-4-15(24)9-19(17)35-14(2)22(33)28-11-23(25,26)27/h4-5,8-10,12,14H,3,6-7,11H2,1-2H3,(H,28,33)(H,29,30,31)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181634 (US9139577, 4.140 | US9708274, 4.140) Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C#N |r| Show InChI InChI=1S/C23H24ClN7O3S/c1-13-9-16(31-35(33)7-4-8-35)10-18-20(13)21(27-12-26-18)29-17-5-6-19(24)30-23(17)34-15(3)22(32)28-14(2)11-25/h5-6,9-10,12,14-15H,4,7-8H2,1-3H3,(H,28,32)(H,26,27,29)/t14-,15+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181635 (US9139577, 4.141 | US9708274, 4.141) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)F |r| Show InChI InChI=1S/C23H24F3N5O3S/c1-13-8-16(31-35(33)6-3-7-35)10-18-21(13)22(29-12-28-18)30-17-5-4-15(24)9-19(17)34-14(2)23(32)27-11-20(25)26/h4-5,8-10,12,14,20H,3,6-7,11H2,1-2H3,(H,27,32)(H,28,29,30)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181642 (US9139577, 5.001 | US9708274, 5.001) Show SMILES C[C@@H](CNS(C)(=O)=O)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O |r| Show InChI InChI=1S/C21H26FN5O4S2/c1-13-8-16(27-32(3,4)28)10-18-20(13)21(24-12-23-18)26-17-7-6-15(22)9-19(17)31-14(2)11-25-33(5,29)30/h6-10,12,14,25H,11H2,1-5H3,(H,23,24,26)/t14-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181665 (US9139577, 7.001 | US9708274, 7.001) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCN(C)CC1)c1cc(C)no1 |r| Show InChI InChI=1S/C26H29FN6O3S/c1-16-11-20(32-37(34)9-7-33(4)8-10-37)14-22-25(16)26(29-15-28-22)30-21-6-5-19(27)13-24(21)35-18(3)23-12-17(2)31-36-23/h5-6,11-15,18H,7-10H2,1-4H3,(H,28,29,30)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181372 (US9139577, 1.003 | US9708274, 1.003) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)C(F)(F)F |r| Show InChI InChI=1S/C19H17ClF4N4O2S/c1-10(19(22,23)24)30-16-6-11(21)4-5-14(16)27-18-17-13(20)7-12(28-31(2,3)29)8-15(17)25-9-26-18/h4-10H,1-3H3,(H,25,26,27)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181385 (US9139577, 1.016 | US9708274, 1.016) Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1 |r| Show InChI InChI=1S/C21H21ClN6O3S/c1-12-8-18(31-27-12)13(2)30-21-16(6-5-7-23-21)26-20-19-15(22)9-14(28-32(3,4)29)10-17(19)24-11-25-20/h5-11,13H,1-4H3,(H,24,25,26)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181388 (US9139577, 1.019 | US9708274, 1.019) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1 |r| Show InChI InChI=1S/C22H21ClFN5O3S/c1-12-7-19(32-28-12)13(2)31-20-8-14(24)5-6-17(20)27-22-21-16(23)9-15(29-33(3,4)30)10-18(21)25-11-26-22/h5-11,13H,1-4H3,(H,25,26,27)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181390 (US9139577, 1.021 | US9708274, 1.021) Show SMILES FCC(CF)Oc1cc(F)ccc1Nc1ncnc2cc(cc(c12)C(F)(F)F)N=S1(=O)CCOCC1 Show InChI InChI=1S/C22H20F6N4O3S/c23-10-15(11-24)35-19-7-13(25)1-2-17(19)31-21-20-16(22(26,27)28)8-14(9-18(20)29-12-30-21)32-36(33)5-3-34-4-6-36/h1-2,7-9,12,15H,3-6,10-11H2,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181397 (US9139577, 2.005 | US9708274, 2.005) Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3OCC3CCOC3)c12)N=S1(=O)CCCC1 Show InChI InChI=1S/C23H27N5O3S/c1-16-11-18(28-32(29)9-2-3-10-32)12-20-21(16)22(26-15-25-20)27-19-5-4-7-24-23(19)31-14-17-6-8-30-13-17/h4-5,7,11-12,15,17H,2-3,6,8-10,13-14H2,1H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181400 (US9139577, 2.008 | US9708274, 2.008) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1 |r| Show InChI InChI=1S/C23H24FN5O3S/c1-13-8-17(29-33(4,5)30)11-19-22(13)23(26-12-25-19)27-18-7-6-16(24)10-21(18)31-15(3)20-9-14(2)28-32-20/h6-12,15H,1-5H3,(H,25,26,27)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181401 (US9139577, 2.009 | US9708274, 2.009) Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)c1cc(C)no1 |r| Show InChI InChI=1S/C24H26N6O3S/c1-15-11-18(30-34(31)9-4-5-10-34)13-20-22(15)23(27-14-26-20)28-19-7-6-8-25-24(19)32-17(3)21-12-16(2)29-33-21/h6-8,11-14,17H,4-5,9-10H2,1-3H3,(H,26,27,28)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181408 (US9139577, 2.016 | US9708274, 2.016) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCNCC1)c1cc(C)no1 |r| Show InChI InChI=1S/C25H27FN6O3S/c1-15-10-19(32-36(33)8-6-27-7-9-36)13-21-24(15)25(29-14-28-21)30-20-5-4-18(26)12-23(20)34-17(3)22-11-16(2)31-35-22/h4-5,10-14,17,27H,6-9H2,1-3H3,(H,28,29,30)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181410 (US9139577, 2.018 | US9708274, 2.018) Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1 |r| Show InChI InChI=1S/C22H24N6O3S/c1-13-9-16(28-32(4,5)29)11-18-20(13)21(25-12-24-18)26-17-7-6-8-23-22(17)30-15(3)19-10-14(2)27-31-19/h6-12,15H,1-5H3,(H,24,25,26)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181411 (US9139577, 2.019 | US9708274, 2.019) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC[C@H](N)C1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C24H26F4N6O3S/c1-13-7-17(34-38(36)6-5-16(29)10-38)9-19-21(13)22(32-12-31-19)33-18-4-3-15(25)8-20(18)37-14(2)23(35)30-11-24(26,27)28/h3-4,7-9,12,14,16H,5-6,10-11,29H2,1-2H3,(H,30,35)(H,31,32,33)/t14-,16+,38?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181418 (US9139577, 2.026 | US9708274, 2.026) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC#N |r| Show InChI InChI=1S/C24H24F2N6O3S/c1-14(23(33)28-7-6-27)35-20-8-15(25)4-5-18(20)31-22-21-17(26)9-16(10-19(21)29-13-30-22)32-36(34)11-24(2,3)12-36/h4-5,8-10,13-14H,7,11-12H2,1-3H3,(H,28,33)(H,29,30,31)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181423 (US9139577, 2.032 | US9708274, 2.032) Show SMILES COC(=O)N1CC2(C1)CS(=O)(C2)=Nc1cc(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2c1 |r| Show InChI InChI=1S/C27H28F4N6O5S/c1-15-6-18(36-43(40)12-26(13-43)10-37(11-26)25(39)41-3)8-20-22(15)23(34-14-33-20)35-19-5-4-17(28)7-21(19)42-16(2)24(38)32-9-27(29,30)31/h4-8,14,16H,9-13H2,1-3H3,(H,32,38)(H,33,34,35)/t16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181425 (US9139577, 2.034 | US9708274, 2.034) Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)N[C@@H](C)C(F)(F)F |r| Show InChI InChI=1S/C26H29ClF3N5O3S/c1-14-8-18(35-39(37)11-25(4,5)12-39)10-20-22(14)23(32-13-31-20)34-19-7-6-17(27)9-21(19)38-15(2)24(36)33-16(3)26(28,29)30/h6-10,13,15-16H,11-12H2,1-5H3,(H,33,36)(H,31,32,34)/t15-,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181432 (US9139577, 2.041 | US9708274, 2.041) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NC(C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C24H22F7N5O3S/c1-12-8-15(36-40(38)6-3-7-40)10-17-19(12)20(33-11-32-17)34-16-5-4-14(25)9-18(16)39-13(2)21(37)35-22(23(26,27)28)24(29,30)31/h4-5,8-11,13,22H,3,6-7H2,1-2H3,(H,35,37)(H,32,33,34)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181435 (US9139577, 2.044 | US9708274, 2.044) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C25H27F4N5O3S/c1-14-7-17(34-38(36)11-24(3,4)12-38)9-19-21(14)22(32-13-31-19)33-18-6-5-16(26)8-20(18)37-15(2)23(35)30-10-25(27,28)29/h5-9,13,15H,10-12H2,1-4H3,(H,30,35)(H,31,32,33)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181436 (US9139577, 2.045 | US9708274, 2.045) Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC2(COC2)C1)C(=O)N[C@@H](C)C(F)(F)F |r| Show InChI InChI=1S/C26H27ClF3N5O4S/c1-14-6-18(35-40(37)11-25(12-40)9-38-10-25)8-20-22(14)23(32-13-31-20)34-19-5-4-17(27)7-21(19)39-15(2)24(36)33-16(3)26(28,29)30/h4-8,13,15-16H,9-12H2,1-3H3,(H,33,36)(H,31,32,34)/t15-,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181444 (US9139577, 3.005 | US9708274, 3.005) Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCC#N)c12)N=S(C)(C)=O Show InChI InChI=1S/C19H18FN5O2S/c1-12-8-14(25-28(2,3)26)10-16-18(12)19(23-11-22-16)24-15-5-4-13(20)9-17(15)27-7-6-21/h4-5,8-11H,7H2,1-3H3,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181445 (US9139577, 3.006 | US9708274, 3.006) Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCC3CCCCO3)c12)N=S(C)(C)=O Show InChI InChI=1S/C23H27FN4O3S/c1-15-10-17(28-32(2,3)29)12-20-22(15)23(26-14-25-20)27-19-8-7-16(24)11-21(19)31-13-18-6-4-5-9-30-18/h7-8,10-12,14,18H,4-6,9,13H2,1-3H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181457 (US9139577, 3.018 | US9708274, 3.018) Show SMILES C[C@H](CN)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O |r| Show InChI InChI=1S/C20H24FN5O2S/c1-12-7-15(26-29(3,4)27)9-17-19(12)20(24-11-23-17)25-16-6-5-14(21)8-18(16)28-13(2)10-22/h5-9,11,13H,10,22H2,1-4H3,(H,23,24,25)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM289150 (US10093660, Example 1.22) Show SMILES O[C@@H]1COC[C@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1 |r| Show InChI InChI=1S/C21H20ClFN4O4S/c22-14-7-13(27-32(29)4-1-5-32)8-16-20(14)21(25-11-24-16)26-15-3-2-12(23)6-18(15)31-19-10-30-9-17(19)28/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATONAL GMBH US Patent					Assay Description ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...				US Patent US10093660 (2018) BindingDB Entry DOI: 10.7270/Q2J67JZG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM289164 (US10093660, Example 1.35) Show SMILES O[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1 |r| Show InChI InChI=1S/C21H20ClFN4O4S/c22-14-7-13(27-32(29)4-1-5-32)8-16-20(14)21(25-11-24-16)26-15-3-2-12(23)6-18(15)31-19-10-30-9-17(19)28/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATONAL GMBH US Patent					Assay Description ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...				US Patent US10093660 (2018) BindingDB Entry DOI: 10.7270/Q2J67JZG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM289370 (US10093660, Example 9.5) Show SMILES COc1cc(cc2ncnc(Nc3ccc(Cl)nc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1 |r| Show InChI InChI=1S/C21H22ClN5O5S/c1-30-16-8-12(27-33(29)5-2-6-33)7-14-19(16)20(24-11-23-14)25-13-3-4-18(22)26-21(13)32-17-10-31-9-15(17)28/h3-4,7-8,11,15,17,28H,2,5-6,9-10H2,1H3,(H,23,24,25)/t15-,17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATONAL GMBH US Patent					Assay Description ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...				US Patent US10093660 (2018) BindingDB Entry DOI: 10.7270/Q2J67JZG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM289396 (US10093660, Example 10.1) Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@H]3OCCF)c12)N=S1(=O)CCCC1 |r| Show InChI InChI=1S/C25H28F2N4O4S/c1-16-10-18(31-36(32)8-2-3-9-36)12-20-24(16)25(29-15-28-20)30-19-5-4-17(27)11-21(19)35-23-14-33-13-22(23)34-7-6-26/h4-5,10-12,15,22-23H,2-3,6-9,13-14H2,1H3,(H,28,29,30)/t22-,23+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATONAL GMBH US Patent					Assay Description ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...				US Patent US10093660 (2018) BindingDB Entry DOI: 10.7270/Q2J67JZG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM289169 (US10093660, Example 14.1 | US10093660, Example 2.2) Show SMILES CO[C@H]1COC[C@H]1Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1 |r| Show InChI InChI=1S/C23H27N5O4S/c1-15-10-16(28-33(29)8-3-4-9-33)11-18-21(15)22(26-14-25-18)27-17-6-5-7-24-23(17)32-20-13-31-12-19(20)30-2/h5-7,10-11,14,19-20H,3-4,8-9,12-13H2,1-2H3,(H,25,26,27)/t19-,20+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATONAL GMBH US Patent					Assay Description ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...				US Patent US10093660 (2018) BindingDB Entry DOI: 10.7270/Q2J67JZG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM289177 (US10093660, Example 14.8 | US10093660, Example 2.9) Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O |r| Show InChI InChI=1S/C22H25FN4O4S/c1-13-7-15(27-32(3,4)28)9-17-21(13)22(25-12-24-17)26-16-6-5-14(23)8-18(16)31-20-11-30-10-19(20)29-2/h5-9,12,19-20H,10-11H2,1-4H3,(H,24,25,26)/t19-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATONAL GMBH US Patent					Assay Description ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...				US Patent US10093660 (2018) BindingDB Entry DOI: 10.7270/Q2J67JZG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181633 (US9139577, 4.139 | US9708274, 4.139) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C23H23F4N5O3S/c1-13-8-16(32-36(34)6-3-7-36)10-18-20(13)21(30-12-29-18)31-17-5-4-15(24)9-19(17)35-14(2)22(33)28-11-23(25,26)27/h4-5,8-10,12,14H,3,6-7,11H2,1-2H3,(H,28,33)(H,29,30,31)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9139577 (2015) BindingDB Entry DOI: 10.7270/Q2K64GT1
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181632 (US9139577, 4.138 | US9708274, 4.138) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C22H20ClF4N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(24)3-4-16(18)31-20-19-15(23)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair

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