Compile Data Set for Download or QSAR

Found 303 hits with Last Name = 'bouyssou' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466600 (US10800757, Compound 16 | US10889568, Compound 16 ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-14-20(19)30-16-5-3-2-4-6-16)22(28)27-11-9-15(10-12-27)17-7-8-21(23)26-25-17/h2-8,13-15H,9-12H2,1H3,(H2,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466599 (US10800757, Compound 15 | US10889568, Compound 15 ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-15-20(19)30-17-5-3-2-4-6-17)22(28)27-11-9-26(10-12-27)16-7-8-21(23)25-14-16/h2-8,13-15H,9-12H2,1H3,(H2,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466665 (US10800757, Compound 80 | US10889568, Compound 80 ...) Show SMILES COc1cc(ncc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C23H22F3N5O4/c1-33-19-12-18(22(32)31-10-8-14(9-11-31)17-6-7-21(27)30-29-17)28-13-20(19)34-15-2-4-16(5-3-15)35-23(24,25)26/h2-7,12-14H,8-11H2,1H3,(H2,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466598 ((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C23H23FN4O3/c1-30-20-12-19(26-14-21(20)31-18-5-3-17(24)4-6-18)23(29)28-10-8-15(9-11-28)16-2-7-22(25)27-13-16/h2-7,12-15H,8-11H2,1H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466597 (US10800757, Compound 13 | US10889568, Compound 13 ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-14-20(19)31-17-5-2-15(23)3-6-17)22(29)28-10-8-27(9-11-28)16-4-7-21(24)26-13-16/h2-7,12-14H,8-11H2,1H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466596 (US10800757, Compound 12 | US10889568, Compound 12 ...) Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(CC2)c2ccc(N)nc2)cc1 Show InChI InChI=1S/C23H25N5O4/c1-30-17-4-6-18(7-5-17)32-21-15-25-19(13-20(21)31-2)23(29)28-11-9-27(10-12-28)16-3-8-22(24)26-14-16/h3-8,13-15H,9-12H2,1-2H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466595 (US10800757, Compound 11 | US10889568, Compound 11 ...) Show SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1 Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-18(26-13-21(19)33-16-5-3-15(24)4-6-16)23(30)29-9-7-14(8-10-29)17-11-20(32-2)22(25)28-27-17/h3-6,11-14H,7-10H2,1-2H3,(H2,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466594 ((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C Show InChI InChI=1S/C24H26N4O3/c1-16-12-23(25)27-14-19(16)17-8-10-28(11-9-17)24(29)20-13-21(30-2)22(15-26-20)31-18-6-4-3-5-7-18/h3-7,12-15,17H,8-11H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466593 (US10800757, Compound 9 | US10889568, Compound 9 | ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C25H26FN5O4/c1-33-20-12-23(27)29-13-19(20)30-9-10-31(25(15-30)7-8-25)24(32)18-11-21(34-2)22(14-28-18)35-17-5-3-16(26)4-6-17/h3-6,11-14H,7-10,15H2,1-2H3,(H2,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466592 (US10800757, Compound 8 | US10889568, Compound 8 | ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C25H27N5O4/c1-32-20-13-23(26)28-14-19(20)29-10-11-30(25(16-29)8-9-25)24(31)18-12-21(33-2)22(15-27-18)34-17-6-4-3-5-7-17/h3-7,12-15H,8-11,16H2,1-2H3,(H2,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466591 (US10800757, Compound 7 | US10889568, Compound 7 | ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C |r| Show InChI InChI=1S/C24H26FN5O4/c1-15-9-23(26)28-11-20(15)29-7-8-30(17(13-29)14-31)24(32)19-10-21(33-2)22(12-27-19)34-18-5-3-16(25)4-6-18/h3-6,9-12,17,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466590 (US10800757, Compound 6 | US10889568, Compound 6 | ...) Show SMILES COc1cc(ncc1Oc1ccc(OC(C)C)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C25H29N5O4/c1-16(2)33-18-4-6-19(7-5-18)34-23-15-27-21(14-22(23)32-3)25(31)30-12-10-17(11-13-30)20-8-9-24(26)29-28-20/h4-9,14-17H,10-13H2,1-3H3,(H2,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466589 (US10800757, Compound 5 | US10889568, Compound 5 | ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C23H25N5O4/c1-30-19-13-22(24)26-14-18(19)27-8-10-28(11-9-27)23(29)17-12-20(31-2)21(15-25-17)32-16-6-4-3-5-7-16/h3-7,12-15H,8-11H2,1-2H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466588 ((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C24H25FN4O4/c1-31-20-12-23(26)28-13-18(20)15-7-9-29(10-8-15)24(30)19-11-21(32-2)22(14-27-19)33-17-5-3-16(25)4-6-17/h3-6,11-15H,7-10H2,1-2H3,(H2,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466587 ((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C23H24N4O3/c1-29-20-13-19(25-15-21(20)30-18-5-3-2-4-6-18)23(28)27-11-9-16(10-12-27)17-7-8-22(24)26-14-17/h2-8,13-16H,9-12H2,1H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466586 ((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C Show InChI InChI=1S/C24H25FN4O3/c1-15-11-23(26)28-13-19(15)16-7-9-29(10-8-16)24(30)20-12-21(31-2)22(14-27-20)32-18-5-3-17(25)4-6-18/h3-6,11-14,16H,7-10H2,1-2H3,(H2,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466585 (US10800757, Compound 1 | US10889568, Compound 1 | ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-22(25)27-13-18(19)28-7-9-29(10-8-28)23(30)17-11-20(32-2)21(14-26-17)33-16-5-3-15(24)4-6-16/h3-6,11-14H,7-10H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466665 (US10800757, Compound 80 | US10889568, Compound 80 ...) Show SMILES COc1cc(ncc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C23H22F3N5O4/c1-33-19-12-18(22(32)31-10-8-14(9-11-31)17-6-7-21(27)30-29-17)28-13-20(19)34-15-2-4-16(5-3-15)35-23(24,25)26/h2-7,12-14H,8-11H2,1H3,(H2,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466585 (US10800757, Compound 1 | US10889568, Compound 1 | ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-22(25)27-13-18(19)28-7-9-29(10-8-28)23(30)17-11-20(32-2)21(14-26-17)33-16-5-3-15(24)4-6-16/h3-6,11-14H,7-10H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466586 ((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C Show InChI InChI=1S/C24H25FN4O3/c1-15-11-23(26)28-13-19(15)16-7-9-29(10-8-16)24(30)20-12-21(31-2)22(14-27-20)32-18-5-3-17(25)4-6-18/h3-6,11-14,16H,7-10H2,1-2H3,(H2,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466587 ((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C23H24N4O3/c1-29-20-13-19(25-15-21(20)30-18-5-3-2-4-6-18)23(28)27-11-9-16(10-12-27)17-7-8-22(24)26-14-17/h2-8,13-16H,9-12H2,1H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466588 ((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C24H25FN4O4/c1-31-20-12-23(26)28-13-18(20)15-7-9-29(10-8-15)24(30)19-11-21(32-2)22(14-27-19)33-17-5-3-16(25)4-6-17/h3-6,11-15H,7-10H2,1-2H3,(H2,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466589 (US10800757, Compound 5 | US10889568, Compound 5 | ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C23H25N5O4/c1-30-19-13-22(24)26-14-18(19)27-8-10-28(11-9-27)23(29)17-12-20(31-2)21(15-25-17)32-16-6-4-3-5-7-16/h3-7,12-15H,8-11H2,1-2H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466590 (US10800757, Compound 6 | US10889568, Compound 6 | ...) Show SMILES COc1cc(ncc1Oc1ccc(OC(C)C)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C25H29N5O4/c1-16(2)33-18-4-6-19(7-5-18)34-23-15-27-21(14-22(23)32-3)25(31)30-12-10-17(11-13-30)20-8-9-24(26)29-28-20/h4-9,14-17H,10-13H2,1-3H3,(H2,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466591 (US10800757, Compound 7 | US10889568, Compound 7 | ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C |r| Show InChI InChI=1S/C24H26FN5O4/c1-15-9-23(26)28-11-20(15)29-7-8-30(17(13-29)14-31)24(32)19-10-21(33-2)22(12-27-19)34-18-5-3-16(25)4-6-18/h3-6,9-12,17,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466592 (US10800757, Compound 8 | US10889568, Compound 8 | ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C25H27N5O4/c1-32-20-13-23(26)28-14-19(20)29-10-11-30(25(16-29)8-9-25)24(31)18-12-21(33-2)22(15-27-18)34-17-6-4-3-5-7-17/h3-7,12-15H,8-11,16H2,1-2H3,(H2,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466593 (US10800757, Compound 9 | US10889568, Compound 9 | ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C25H26FN5O4/c1-33-20-12-23(27)29-13-19(20)30-9-10-31(25(15-30)7-8-25)24(32)18-11-21(34-2)22(14-28-18)35-17-5-3-16(26)4-6-17/h3-6,11-14H,7-10,15H2,1-2H3,(H2,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466594 ((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C Show InChI InChI=1S/C24H26N4O3/c1-16-12-23(25)27-14-19(16)17-8-10-28(11-9-17)24(29)20-13-21(30-2)22(15-26-20)31-18-6-4-3-5-7-18/h3-7,12-15,17H,8-11H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466595 (US10800757, Compound 11 | US10889568, Compound 11 ...) Show SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1 Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-18(26-13-21(19)33-16-5-3-15(24)4-6-16)23(30)29-9-7-14(8-10-29)17-11-20(32-2)22(25)28-27-17/h3-6,11-14H,7-10H2,1-2H3,(H2,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466596 (US10800757, Compound 12 | US10889568, Compound 12 ...) Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(CC2)c2ccc(N)nc2)cc1 Show InChI InChI=1S/C23H25N5O4/c1-30-17-4-6-18(7-5-17)32-21-15-25-19(13-20(21)31-2)23(29)28-11-9-27(10-12-28)16-3-8-22(24)26-14-16/h3-8,13-15H,9-12H2,1-2H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466597 (US10800757, Compound 13 | US10889568, Compound 13 ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-14-20(19)31-17-5-2-15(23)3-6-17)22(29)28-10-8-27(9-11-28)16-4-7-21(24)26-13-16/h2-7,12-14H,8-11H2,1H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466598 ((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C23H23FN4O3/c1-30-20-12-19(26-14-21(20)31-18-5-3-17(24)4-6-18)23(29)28-10-8-15(9-11-28)16-2-7-22(25)27-13-16/h2-7,12-15H,8-11H2,1H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466599 (US10800757, Compound 15 | US10889568, Compound 15 ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1ccc(N)nc1 Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-15-20(19)30-17-5-3-2-4-6-17)22(28)27-11-9-26(10-12-27)16-7-8-21(23)25-14-16/h2-8,13-15H,9-12H2,1H3,(H2,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466600 (US10800757, Compound 16 | US10889568, Compound 16 ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-14-20(19)30-16-5-3-2-4-6-16)22(28)27-11-9-15(10-12-27)17-7-8-21(23)26-25-17/h2-8,13-15H,9-12H2,1H3,(H2,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466601 (US10800757, Compound 17 | US10889568, Compound 17 ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-13-20(19)31-16-4-2-15(23)3-5-16)22(29)28-10-8-14(9-11-28)17-6-7-21(24)27-26-17/h2-7,12-14H,8-11H2,1H3,(H2,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466601 (US10800757, Compound 17 | US10889568, Compound 17 ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1 Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-13-20(19)31-16-4-2-15(23)3-5-16)22(29)28-10-8-14(9-11-28)17-6-7-21(24)27-26-17/h2-7,12-14H,8-11H2,1H3,(H2,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466602 (US10800757, Compound 18 | US10889568, Compound 18 ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C |r| Show InChI InChI=1S/C24H27N5O4/c1-16-10-23(25)27-12-20(16)28-8-9-29(17(14-28)15-30)24(31)19-11-21(32-2)22(13-26-19)33-18-6-4-3-5-7-18/h3-7,10-13,17,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466602 (US10800757, Compound 18 | US10889568, Compound 18 ...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C |r| Show InChI InChI=1S/C24H27N5O4/c1-16-10-23(25)27-12-20(16)28-8-9-29(17(14-28)15-30)24(31)19-11-21(32-2)22(13-26-19)33-18-6-4-3-5-7-18/h3-7,10-13,17,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466603 ((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...) Show SMILES COc1cc(ncc1OCc1ccccc1F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C25H27FN4O4/c1-32-21-12-24(27)29-13-18(21)16-7-9-30(10-8-16)25(31)20-11-22(33-2)23(14-28-20)34-15-17-5-3-4-6-19(17)26/h3-6,11-14,16H,7-10,15H2,1-2H3,(H2,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466603 ((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...) Show SMILES COc1cc(ncc1OCc1ccccc1F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C25H27FN4O4/c1-32-21-12-24(27)29-13-18(21)16-7-9-30(10-8-16)25(31)20-11-22(33-2)23(14-28-20)34-15-17-5-3-4-6-19(17)26/h3-6,11-14,16H,7-10,15H2,1-2H3,(H2,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466604 (US10800757, Compound 20 | US10800757, Compound 81 ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1ccc(N)nc1 |r| Show InChI InChI=1S/C23H24FN5O4/c1-32-20-10-19(26-12-21(20)33-18-5-2-15(24)3-6-18)23(31)29-9-8-28(13-17(29)14-30)16-4-7-22(25)27-11-16/h2-7,10-12,17,30H,8-9,13-14H2,1H3,(H2,25,27)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466604 (US10800757, Compound 20 | US10800757, Compound 81 ...) Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1ccc(N)nc1 |r| Show InChI InChI=1S/C23H24FN5O4/c1-32-20-10-19(26-12-21(20)33-18-5-2-15(24)3-6-18)23(31)29-9-8-28(13-17(29)14-30)16-4-7-22(25)27-11-16/h2-7,10-12,17,30H,8-9,13-14H2,1H3,(H2,25,27)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466605 (US10800757, Compound 21 | [4-(6-Amino-5-methoxy-py...) Show SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1 Show InChI InChI=1S/C23H25N5O4/c1-30-19-13-18(25-14-21(19)32-16-6-4-3-5-7-16)23(29)28-10-8-15(9-11-28)17-12-20(31-2)22(24)27-26-17/h3-7,12-15H,8-11H2,1-2H3,(H2,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM477646 (US10889568, Compound 21 | [4-(6-Amino-5-methoxy-py...) Show SMILES COc1cc(nnc1C)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1 Show InChI InChI=1S/C24H26N4O4/c1-16-21(30-2)13-19(27-26-16)17-9-11-28(12-10-17)24(29)20-14-22(31-3)23(15-25-20)32-18-7-5-4-6-8-18/h4-8,13-15,17H,9-12H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466606 ((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...) Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nc2)cc1 Show InChI InChI=1S/C24H26N4O4/c1-30-18-4-6-19(7-5-18)32-22-15-26-20(13-21(22)31-2)24(29)28-11-9-16(10-12-28)17-3-8-23(25)27-14-17/h3-8,13-16H,9-12H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466606 ((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...) Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nc2)cc1 Show InChI InChI=1S/C24H26N4O4/c1-30-18-4-6-19(7-5-18)32-22-15-26-20(13-21(22)31-2)24(29)28-11-9-16(10-12-28)17-3-8-23(25)27-14-17/h3-8,13-16H,9-12H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466634 ((1R)-1-[(2R)-4-(6-amino-4- methoxypyridin-3-yl)-1-...) Show SMILES COc1cc(N)ncc1N1CCN([C@H](C1)[C@@H](C)O)C(=O)c1ccc(Oc2ccccc2)cn1 |r| Show InChI InChI=1S/C24H27N5O4/c1-16(30)21-15-28(20-14-27-23(25)12-22(20)32-2)10-11-29(21)24(31)19-9-8-18(13-26-19)33-17-6-4-3-5-7-17/h3-9,12-14,16,21,30H,10-11,15H2,1-2H3,(H2,25,27)/t16-,21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466634 ((1R)-1-[(2R)-4-(6-amino-4- methoxypyridin-3-yl)-1-...) Show SMILES COc1cc(N)ncc1N1CCN([C@H](C1)[C@@H](C)O)C(=O)c1ccc(Oc2ccccc2)cn1 |r| Show InChI InChI=1S/C24H27N5O4/c1-16(30)21-15-28(20-14-27-23(25)12-22(20)32-2)10-11-29(21)24(31)19-9-8-18(13-26-19)33-17-6-4-3-5-7-17/h3-9,12-14,16,21,30H,10-11,15H2,1-2H3,(H2,25,27)/t16-,21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466607 ((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C24H26N4O4/c1-30-20-13-23(25)27-14-18(20)16-8-10-28(11-9-16)24(29)19-12-21(31-2)22(15-26-19)32-17-6-4-3-5-7-17/h3-7,12-16H,8-11H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466607 ((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...) Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC Show InChI InChI=1S/C24H26N4O4/c1-30-20-13-23(25)27-14-18(20)16-8-10-28(11-9-16)24(29)19-12-21(31-2)22(15-26-19)32-17-6-4-3-5-7-17/h3-7,12-16H,8-11H2,1-2H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair

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