| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
|---|
| Ligand | BDBM370113 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CDK4/Cyclin D3 Mobility Shift Assay |
|---|
| Ki | 1.55±n/a nM |
|---|
| Citation |  Behenna, DC; Chen, P; Freeman-Cook, KD; Hoffman, RL; Jalaie, M; Nagata, A; Nair, SK; Ninkovic, S; Ornelas, MA; Palmer, CL; Rui, EY CDK2/4/6 inhibitors US Patent US10800783 Publication Date 10/13/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
|---|
| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CDK4/Cyclin D3 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1806445 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
|---|
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33731.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11802 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CCND3 | CCND3_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32521.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30281 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
|
|
|
|---|
| BDBM370113 |
|---|
| n/a |
|---|
| Name | BDBM370113 |
|---|
| Synonyms: | 8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one | US10233188, Example 2 | US10800783, Example 2 | US11396512, Example 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H27N5O4S |
|---|
| Mol. Mass. | 421.514 |
|---|
| SMILES | C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2ccc1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
