Reaction Details |
| Report a problem with these data |
Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
---|
Ligand | BDBM370162 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | CDK6/Cyclin D1 Mobility Shift Assay |
---|
Ki | 0.080±n/a nM |
---|
Citation | Behenna, DC; Chen, P; Freeman-Cook, KD; Hoffman, RL; Jalaie, M; Nagata, A; Nair, SK; Ninkovic, S; Ornelas, MA; Palmer, CL; Rui, EY CDK2/4/6 inhibitors US Patent US10800783 Publication Date 10/13/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
---|
Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
Synonyms: | CDK6/Cyclin D1 |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
|
|
|
Component 2 |
Name: | G1/S-specific cyclin-D1 |
Synonyms: | CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33418.84 |
Organism: | Mus musculus (mouse) |
Description: | n/a |
Residue: | 295 |
Sequence: | MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
|
|
|
BDBM370162 |
---|
n/a |
---|
Name | BDBM370162 |
Synonyms: | US10233188, Example 50 | US10800783, Example 50 | US11396512, Example 50 |
Type | Small organic molecule |
Emp. Form. | C20H29N5O4S |
Mol. Mass. | 435.54 |
SMILES | C[C@H]1CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(CO)c1=O |r| |
Structure |
|