| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1/M2 |
|---|
| Ligand | BDBM477447 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Effect |
|---|
| IC50 | 50.0±n/a nM |
|---|
| Citation |  Miyahara, S; Ueno, H; Hara, S; Ogino, Y Sulfonamide compound or salt thereof US Patent US10889555 Publication Date 1/12/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M1/M2 |
|---|
| Name: | Muscarinic acetylcholine receptor M1/M2 |
|---|
| Synonyms: | Human RNR |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Muscarinic acetylcholine receptor M1 |
|---|
| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51442.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11229 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
|
|
|
|---|
| Component 2 |
| Name: | Muscarinic acetylcholine receptor M2 |
|---|
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
|---|
| Type: | GPCR |
|---|
| Mol. Mass.: | 51730.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08172 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
|---|
| BDBM477447 |
|---|
| n/a |
|---|
| Name | BDBM477447 |
|---|
| Synonyms: | 5-fluoro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5- | US10889555, Example 224A | US10889555, Example 227A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22BrF2N3O6S |
|---|
| Mol. Mass. | 574.392 |
|---|
| SMILES | C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
