| Reaction Details |
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 | Report a problem with these data |
| Target | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Ligand | BDBM50241837 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | >100.0±n/a nM |
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| Citation |  Landry, DW; Deng, S; Arancio, O; Fiorito, J; Wasmuth, A Phosphodiesterase inhibitors and uses thereof US Patent US10899756 Publication Date 1/26/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Synonyms: | PDE6A | PDE6A_HUMAN | PDEA | Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99531.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1347866 |
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| Residue: | 860 |
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| Sequence: | MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ
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| BDBM50241837 |
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| n/a |
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| Name | BDBM50241837 |
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| Synonyms: | CHEMBL4102913 | US10626113, Compound G | US10899756, Compound G |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19ClN4O |
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| Mol. Mass. | 378.855 |
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| SMILES | COc1ccc(CNc2c3CNCCc3nc3ccc(cc23)C#N)cc1Cl |
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| Structure | 
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