Reaction Details |
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Target | SH2B adapter protein 2 |
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Ligand | BDBM484438 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 10.00±n/a nM |
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Citation | Chen, Z; Fortanet, JG; Karki, R; Lamarche, MJ; Majumdar, D; Perez, LB; Sendzik, M; Smith, TD; Yang, F; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent US10934285 Publication Date 3/2/2021 |
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More Info.: | Get all data from this article, Assay Method |
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SH2B adapter protein 2 |
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Name: | SH2B adapter protein 2 |
Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
Type: | Protein |
Mol. Mass.: | 67733.52 |
Organism: | Human |
Description: | O14492 |
Residue: | 632 |
Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
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BDBM484438 |
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n/a |
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Name | BDBM484438 |
Synonyms: | US10934285, Example 22 |
Type | Small organic molecule |
Emp. Form. | C28H27ClF2N8O3S |
Mol. Mass. | 629.081 |
SMILES | N[C@@H]1C(F)(F)CCC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1 |r| |
Structure |
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