| Reaction Details |
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 | Report a problem with these data |
| Target | SH2B adapter protein 2 |
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| Ligand | BDBM484459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 7.00±n/a nM |
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| Citation |  Chen, Z; Fortanet, JG; Karki, R; Lamarche, MJ; Majumdar, D; Perez, LB; Sendzik, M; Smith, TD; Yang, F; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent US10934285 Publication Date 3/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| SH2B adapter protein 2 |
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| Name: | SH2B adapter protein 2 |
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| Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 67733.52 |
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| Organism: | Human |
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| Description: | O14492 |
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| Residue: | 632 |
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| Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
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| BDBM484459 |
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| n/a |
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| Name | BDBM484459 |
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| Synonyms: | US10934285, Example 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30ClN7O3S |
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| Mol. Mass. | 556.08 |
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| SMILES | CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)cn1 |
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| Structure | 
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