| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 2 |
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| Ligand | BDBM486442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzymatic BACE1 and BACE2 FRET (Fluorescence Resonance Energy Transfer) Assays |
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| IC50 | 375±n/a nM |
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| Citation |  Allen, JR; Bourbeau, MP; Chen, N; Frohn, MJ; Harrington, PE; Liu, Q; Reeves, C Substituted oxazines as beta-secretase inhibitors US Patent US10947223 Publication Date 3/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 2 |
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| Name: | Beta-secretase 2 |
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| Synonyms: | BACE2_MOUSE | Bace2 | Beta-secretase 2 (BACE2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55787.27 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9JL18 |
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| Residue: | 514 |
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| Sequence: | MGALLRALLLLVLAQWLLSAVPALAPAPFTLPLQVAGATNHRASAVPGLGTPELPRADGL
ALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
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| BDBM486442 |
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| n/a |
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| Name | BDBM486442 |
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| Synonyms: | (2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine | US10947223, Example 107 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19F5N4O2 |
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| Mol. Mass. | 466.4039 |
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| SMILES | C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F |r,c:7| |
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| Structure | 
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