| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [866-1154] |
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| Ligand | BDBM488719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | <3.00±n/a nM |
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| Citation |  Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent US10961228 Publication Date 3/30/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [866-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [866-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
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| Type: | Protein |
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| Mol. Mass.: | 33185.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[866-1154] |
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| Residue: | 289 |
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| Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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| BDBM488719 |
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| n/a |
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| Name | BDBM488719 |
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| Synonyms: | (R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide | US10961228, Example 26 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36FN7O3S |
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| Mol. Mass. | 593.715 |
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| SMILES | CC[C@@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C |r| |
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| Structure | 
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