| Reaction Details |
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 | Report a problem with these data |
| Target | Plasma kallikrein |
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| Ligand | BDBM283417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzyme Inhibition |
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| IC50 | <100±n/a nM |
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| Citation |  McDonald, A; Qian, S Therapeutic inhibitory compounds US Patent US11021463 Publication Date 6/1/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasma kallikrein |
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| Name: | Plasma kallikrein |
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| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
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| Type: | Protein |
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| Mol. Mass.: | 71391.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03952 |
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| Residue: | 638 |
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| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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| BDBM283417 |
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| n/a |
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| Name | BDBM283417 |
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| Synonyms: | N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-chloro-8-(methylsulfonyl)quinolin-6- yl)methyl)isonicotinamide | US10023557, Example 69 | US10266515, Example 69 | US10308637, Example 69 | US11021463, Example 69 | US9611252, Example 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClN5O3S |
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| Mol. Mass. | 495.981 |
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| SMILES | Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(c3ncc(Cl)cc3c2)S(C)(=O)=O)c1 |
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| Structure | 
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