BindingDB PrimarySearch

Found 2467 hits with Last Name = 'mcdonald' and Initial = 'a'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20458 (1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	7	-46.5	n/a	n/a	5	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20464 ((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	27	-43.2	n/a	n/a	34	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50246766 (CHEMBL489079 \| Mofegiline \| US9302986, Mofegiline) Show SMILES NC\C(CCc1ccc(F)cc1)=C\F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOB expressed in Pichia pastoris by kinetic assay				J Med Chem 51: 8019-26 (2008) Article DOI: 10.1021/jm8011867 BindingDB Entry DOI: 10.7270/Q2542NGF
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20334 (1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	47	-41.8	n/a	n/a	11	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20465 (1-[(1R,2S)-6-fluoro-1-{[3-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	58	-41.3	n/a	n/a	46	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
p-hydroxybenzoate hydroxylase (Pseudomonas fluorescens)	BDBM50038194 (2-Benzyloxy-4-hydroxy-benzoic acid \| CHEMBL130259) Show SMILES OC(=O)c1ccc(O)cc1OCc1ccccc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Marion Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity of the compound against p-hydroxybenzoate hydroxylase (PHBH) from Pseudomonas fluorescence competing with p-hydroxy benzoic acid				J Med Chem 37: 4076-8 (1995) BindingDB Entry DOI: 10.7270/Q2959GKZ
Marion Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20285 (Resiniferatoxin \| [(1R,2R,6R,10S,11R,15R,17R)-13-b...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	65	-41.0	n/a	n/a	24	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
p-hydroxybenzoate hydroxylase (Pseudomonas fluorescens)	BDBM50038194 (2-Benzyloxy-4-hydroxy-benzoic acid \| CHEMBL130259) Show SMILES OC(=O)c1ccc(O)cc1OCc1ccccc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	69	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Marion Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity of the compound against p-hydroxybenzoate hydroxylase (PHBH) from Pseudomonas fluorescence competing with NADPH				J Med Chem 37: 4076-8 (1995) BindingDB Entry DOI: 10.7270/Q2959GKZ
Marion Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20466 (A-784168 \| CHEMBL482834 \| N-[4-(trifluoromethane)s...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	71	-40.8	n/a	n/a	74	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20467 (3-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-1-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	112	-39.7	n/a	n/a	34	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20459 (Tinyatoxin \| [(1R,2R,6R,10S,11R,15R,17R)-13-benzyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	589	-35.6	n/a	n/a	129	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20468 (3-(2-bromophenyl)-1-{2-[ethyl(3-methylphenyl)amino...) Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	603	-35.5	n/a	n/a	95	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] A (Homo sapiens (Human))	BDBM50246766 (CHEMBL489079 \| Mofegiline \| US9302986, Mofegiline) Show SMILES NC\C(CCc1ccc(F)cc1)=C\F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOA expressed in Pichia pastoris by kinetic assay				J Med Chem 51: 8019-26 (2008) Article DOI: 10.1021/jm8011867 BindingDB Entry DOI: 10.7270/Q2542NGF
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20284 (CHEMBL391997 \| CPZ \| Capsazepine \| N-[2-(4-chlorop...) Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.29E+3	-33.6	n/a	n/a	282	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.59E+3	-33.1	n/a	n/a	132	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Membrane primary amine oxidase (Homo sapiens (Human))	BDBM50246766 (CHEMBL489079 \| Mofegiline \| US9302986, Mofegiline) Show SMILES NC\C(CCc1ccc(F)cc1)=C\F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaxis Ltd. Curated by ChEMBL					Assay Description Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysis				Bioorg Med Chem Lett 22: 3935-40 (2012) Article DOI: 10.1016/j.bmcl.2012.04.111 BindingDB Entry DOI: 10.7270/Q2SQ91D6
Pharmaxis Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Membrane primary amine oxidase (Homo sapiens (Human))	BDBM50384084 (CHEMBL2029546) Show SMILES NC\C=C(\F)COc1ccc(cc1)C(=O)NC1CCCCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaxis Ltd. Curated by ChEMBL					Assay Description Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysis				Bioorg Med Chem Lett 22: 3935-40 (2012) Article DOI: 10.1016/j.bmcl.2012.04.111 BindingDB Entry DOI: 10.7270/Q2SQ91D6
Pharmaxis Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20462 ((5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]ic...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>6.31E+3	>-29.7	n/a	n/a	1.48E+3	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20461 ((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...) Show SMILES COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.00E+4	-26.8	n/a	n/a	29	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
Abbott Laboratories					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] A (Homo sapiens (Human))	BDBM50113840 (4-Phenyl-butylamine \| 4-phenylbutylamine \| CHEMBL7...) Show SMILES NCCCCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of human MAOA				J Med Chem 51: 8019-26 (2008) Article DOI: 10.1021/jm8011867 BindingDB Entry DOI: 10.7270/Q2542NGF
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50010893 ((R)-2-Amino-4-oxo-5-phosphono-pentanoic acid \| 2-A...) Show SMILES N[C@H](CC(=O)CP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus)	BDBM50004897 ((APV)2-Amino-5-phosphono-pentanoic acid \| (R)-2-Am...) Show SMILES NC(CCCP(O)(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus)	BDBM50002360 ((CPP)4-(3-Phosphono-propyl)-piperazine-2-carboxyli...) Show SMILES OC(=O)C1CN(CCCP(O)(O)=O)CCN1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50004927 (4-Phosphonomethyl-piperidine-2-carboxylic acid \| 4...) Show SMILES OC(=O)[C@@H]1C[C@H](CP(O)(O)=O)CCN1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus)	BDBM50004927 (4-Phosphonomethyl-piperidine-2-carboxylic acid \| 4...) Show SMILES OC(=O)[C@@H]1C[C@H](CP(O)(O)=O)CCN1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50002363 ((APH)2-Amino-7-phosphono-heptanoic acid \| 2-Amino-...) Show SMILES NC(CCCCCP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50004897 ((APV)2-Amino-5-phosphono-pentanoic acid \| (R)-2-Am...) Show SMILES NC(CCCP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50002360 ((CPP)4-(3-Phosphono-propyl)-piperazine-2-carboxyli...) Show SMILES OC(=O)C1CN(CCCP(O)(O)=O)CCN1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus)	BDBM50002363 ((APH)2-Amino-7-phosphono-heptanoic acid \| 2-Amino-...) Show SMILES NC(CCCCCP(O)(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus)	BDBM50010893 ((R)-2-Amino-4-oxo-5-phosphono-pentanoic acid \| 2-A...) Show SMILES N[C@H](CC(=O)CP(O)(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merrell Dow Research Institute Curated by ChEMBL					Assay Description Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; Inactive				J Med Chem 33: 2961-3 (1990) BindingDB Entry DOI: 10.7270/Q2BK1CXM
Merrell Dow Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50232114 ((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	5.5	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Blockade of pH 5.5-induced activation of TRPV1				J Med Chem 51: 392-5 (2008) Article DOI: 10.1021/jm701007g BindingDB Entry DOI: 10.7270/Q218367F
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50321857 (8-{4-(4-Fluorophenyl)-5-[4-(trifluoromethyl)phenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor expressed in human 1321 cells assessed as inhibition of capsaicin-induced in intracellular ca...				Bioorg Med Chem 18: 4821-9 (2011) Article DOI: 10.1016/j.bmc.2010.04.099 BindingDB Entry DOI: 10.7270/Q27H1KJJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50228080 (2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrof...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by ...				J Nat Prod 72: 1944-8 (2009) Article DOI: 10.1021/np9004882 BindingDB Entry DOI: 10.7270/Q2R49RQR
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM128907 (US8802711, 76) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...				US Patent US8802711 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28NC
AbbVie Inc. US Patent					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50056351 (CHEMBL3326569) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay				J Med Chem 57: 7412-24 (2014) Article DOI: 10.1021/jm500916t BindingDB Entry DOI: 10.7270/Q2Z3219J
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50321856 (4-{2-[7-Hydroxy-5,6,7,8-tetrahydronaphthalen-1-yla...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor expressed in human 1321 cells assessed as inhibition of capsaicin-induced in intracellular ca...				Bioorg Med Chem 18: 4821-9 (2011) Article DOI: 10.1016/j.bmc.2010.04.099 BindingDB Entry DOI: 10.7270/Q27H1KJJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50321853 (8-{4-Ethyl-5-[4-(trifluoromethyl)phenyl]oxazol-2-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor expressed in human 1321 cells assessed as inhibition of capsaicin-induced in intracellular ca...				Bioorg Med Chem 18: 4821-9 (2011) Article DOI: 10.1016/j.bmc.2010.04.099 BindingDB Entry DOI: 10.7270/Q27H1KJJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM128912 (US8802711, 81) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...				US Patent US8802711 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28NC
AbbVie Inc. US Patent					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-9 (RAT)	BDBM82070 (CAS_29790-52-1 \| NICOTINE-L (BASE) \| Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
SIBIA Neurosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards Nicotinic acetylcholine receptor by the displacement of [3H]-nicotine from rat cortical membranes				J Med Chem 42: 1684-6 (1999) Article DOI: 10.1021/jm990035d BindingDB Entry DOI: 10.7270/Q2QC02PQ
SIBIA Neurosciences Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50338002 ((R)-1-(8-tert-butylchroman-4-yl)-3-(1H-indazol-4-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of calcium influx				Bioorg Med Chem Lett 21: 1338-41 (2011) Article DOI: 10.1016/j.bmcl.2011.01.056 BindingDB Entry DOI: 10.7270/Q20K28W6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50056358 (CHEMBL3326581) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay				J Med Chem 57: 7412-24 (2014) Article DOI: 10.1021/jm500916t BindingDB Entry DOI: 10.7270/Q2Z3219J
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50232113 (1-(1H-indazol-4-yl)-3-(5-(trifluoromethyl)-2,3-dih...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux				J Med Chem 51: 392-5 (2008) Article DOI: 10.1021/jm701007g BindingDB Entry DOI: 10.7270/Q218367F
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50232113 (1-(1H-indazol-4-yl)-3-(5-(trifluoromethyl)-2,3-dih...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of calcium influx				Bioorg Med Chem Lett 21: 1338-41 (2011) Article DOI: 10.1016/j.bmcl.2011.01.056 BindingDB Entry DOI: 10.7270/Q20K28W6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50232114 ((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Blockade of N-arachidonoyl-dopamine-induced activation of TRPV1				J Med Chem 51: 392-5 (2008) Article DOI: 10.1021/jm701007g BindingDB Entry DOI: 10.7270/Q218367F
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM18627 ((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...				J Nat Prod 72: 1944-8 (2009) Article DOI: 10.1021/np9004882 BindingDB Entry DOI: 10.7270/Q2R49RQR
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50321850 (8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor expressed in human 1321 cells assessed as inhibition of capsaicin-induced in intracellular ca...				Bioorg Med Chem 18: 4821-9 (2011) Article DOI: 10.1016/j.bmc.2010.04.099 BindingDB Entry DOI: 10.7270/Q27H1KJJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM128913 (US8802711, 82) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...				US Patent US8802711 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28NC
AbbVie Inc. US Patent					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM128905 (US8802711, 74) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...				US Patent US8802711 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28NC
AbbVie Inc. US Patent					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319456 (1-(1H-indazol-4-yl)-3-((2-(piperidin-1-yl)-6-(trif...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM50246766 (CHEMBL489079 \| Mofegiline \| US9302986, Mofegiline) Show SMILES NC\C(CCc1ccc(F)cc1)=C\F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of rat membrane MAOB				J Med Chem 51: 8019-26 (2008) Article DOI: 10.1021/jm8011867 BindingDB Entry DOI: 10.7270/Q2542NGF
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair

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