null

SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1

InChI Key InChIKey=HKTBYUWLRDZAJK-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263263   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56P2WPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736V7KPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human N-terminal DYKDDDDK-tagged MNK1(1 to 424 residues) expressed in baculovirus expression system using TATKSGSTTKNR as s...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V128D5PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50T2PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed