null
SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
InChI Key InChIKey=HKTBYUWLRDZAJK-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50263263
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo...More data for this Ligand-Target Pair
3D Structure (crystal)TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
Curated by ChEMBL
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
Curated by ChEMBL
Affinity DataIC50: 787nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
Curated by ChEMBL
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
Curated by ChEMBL
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
Curated by ChEMBL
Affinity DataIC50: 131nMAssay Description:Inhibition of DRAK1 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MNK2 (1 to 465 residues) expressed in baculovirus expression system using TATKSGSTTKNR as subst...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human N-terminal DYKDDDDK-tagged MNK1(1 to 424 residues) expressed in baculovirus expression system using TATKSGSTTKNR as s...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair