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SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Br)cccc1Br

InChI Key InChIKey=HGIPWJYTPOHUGK-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 3436   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48DGPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48DGPubMed
TargetBiotin carboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)
Achaogen Inc.

Curated by ChEMBL
LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant N-terminal His-tagged Pseudomonas aeruginosa PAO1 biotin carboxylase expressed in Escherichia coli Rosetta(DE3) pLysS cells...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ14G4PubMed
TargetBiotin carboxylase(Escherichia coli (strain K12))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:Assays were performed in 384-well clear bottom plates (Corning; catalog no. 3702), that contained inhibitor solvated in DMSO. To each well of the pla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48DGPubMed