Compile Data Set for Download or QSAR
Found 264 with Last Name = 'eam' and Initial = 'b'
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263270(CHEMBL4086747)copy SMILEScopy InChI
Affinity DataIC50: 0.0840nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263254(CHEMBL4094975)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263253(CHEMBL4067557)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168214(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263270(CHEMBL4086747)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168214(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)copy SMILEScopy InChI
Affinity DataIC50: 0.510nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263254(CHEMBL4094975)copy SMILEScopy InChI
Affinity DataIC50: 0.620nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263269(CHEMBL4076439)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263269(CHEMBL4076439)copy SMILEScopy InChI
Affinity DataIC50: 0.680nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263269(CHEMBL4076439)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263254(CHEMBL4094975)copy SMILEScopy InChI
Affinity DataIC50: 0.880nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263255(CHEMBL4065802)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168222(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263255(CHEMBL4065802)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263264(CHEMBL4094080)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168222(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168214(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168222(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM297345(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)c...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263253(CHEMBL4067557)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576672(CHEMBL4857096)copy SMILES
Affinity DataIC50: 2.30nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM164271(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168241(US9669031, 69 8-fluoro-3,3-dimethyl-6-(pyrimidin-4...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM164271(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576670(CHEMBL4864162)copy SMILES
Affinity DataIC50: 5nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576669(CHEMBL4855528)copy SMILES
Affinity DataIC50: 5.60nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM297345(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)c...)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168241(US9669031, 69 8-fluoro-3,3-dimethyl-6-(pyrimidin-4...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263264(CHEMBL4094080)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168239(US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576673(CHEMBL4849769)copy SMILES
Affinity DataIC50: 10nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576672(CHEMBL4857096)copy SMILES
Affinity DataIC50: 11nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263253(CHEMBL4067557)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM164271(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM168239(US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetAdenylate cyclase type 1(Homo sapiens (Human))
Food and Drug Administration

Curated by ChEMBL
LigandPNGBDBM50052137(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of [125 I]-6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34WJGPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576670(CHEMBL4864162)copy SMILES
Affinity DataIC50: 21nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576669(CHEMBL4855528)copy SMILES
Affinity DataIC50: 22nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM297336(5-((9H-purin-6-yl)amino)isoindolin-1-one (Cpd. No....)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

Curated by ChEMBL
LigandPNGBDBM50263255(CHEMBL4065802)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC63PSPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50576671(CHEMBL4875109)copy SMILES
Affinity DataIC50: 25nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ72K9PubMed
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