Compile Data Set for Download or QSAR
Found 142 with Last Name = 'huang' and Initial = 'xf'
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50098378((1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosp...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate incubated for 10 mi...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PDE2 (unknown origin) using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50443054(CHEMBL3087934 | US11279719, Example C-12)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386555(CHEMBL2048241)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386558(CHEMBL2048244)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386556(CHEMBL2048242)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386557(CHEMBL2048243)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520638(CHEMBL4471037 | US11279719, Example I-18)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520641(CHEMBL4455060 | US11279719, Example I-13)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520640(CHEMBL4472025 | US11279719, Example I-34)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386552(CHEMBL2048238)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520639(CHEMBL4465832 | US11279719, Example I-6)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520639(CHEMBL4465832 | US11279719, Example I-6)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520641(CHEMBL4455060 | US11279719, Example I-13)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50518536(CHEMBL4580973)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB4947PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520643(CHEMBL4538679 | US11279719, Example I-39)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520637(CHEMBL4577077 | US11279719, Example I-37)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50518534(CHEMBL4591047)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB4947PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520645(CHEMBL2347859 | US11279719, Example C-5)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520646(CHEMBL4564934 | US11279719, Example I-5)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50115104((pyridin-2-ylamino)methylenediphosphonic acid | 2-...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520637(CHEMBL4577077 | US11279719, Example I-37)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50542296(CHEMBL4641729)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KKDPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520646(CHEMBL4564934 | US11279719, Example I-5)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520642(CHEMBL2347861 | US11279719, Example C-10)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520638(CHEMBL4471037 | US11279719, Example I-18)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human FPPS using FPP and [3H]-IPP as substrate incubated for 30 mins prior to substrate addition measured after 20 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50542291(CHEMBL4642376)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KKDPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386550(CHEMBL2048236)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386553(CHEMBL2048239)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386551(CHEMBL2048237)copy SMILEScopy InChI
Affinity DataIC50: 164nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520642(CHEMBL2347861 | US11279719, Example C-10)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50542297(CHEMBL4638267)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KKDPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant GGPPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50518553(CHEMBL4453746)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB4947PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50542295(CHEMBL4639873)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KKDPubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25270([(6E,11E)-2,6,12,16-tetramethyl-9-phosphonoheptade...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25270([(6E,11E)-2,6,12,16-tetramethyl-9-phosphonoheptade...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386554(CHEMBL2048240)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)copy SMILEScopy InChI
Affinity DataIC50: 475nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 10 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50327500(2-(5-(1H-indazol-5-yl)pyridin-3-yl)-1-fluoroethane...)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50520645(CHEMBL2347859 | US11279719, Example C-5)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50518537(CHEMBL4458207)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB4947PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25270([(6E,11E)-2,6,12,16-tetramethyl-9-phosphonoheptade...)copy SMILEScopy InChI
Affinity DataIC50: 590nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8HWFPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50542277(CHEMBL4638436)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KKDPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50542292(CHEMBL4643394)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KKDPubMed
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