Found 35 Enz. Inhib. hit(s) with all data for entry = 50007292 TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human A431 cell-derived EGFR assessed as reduction in PGT phosphorylation after 8 mins by colorimetry based immunoassayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human A431 cell-derived EGFRMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human GST-fused B-Raf V600E mutant using MEK1 as substrate measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 9.60nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of EGF-induced EGFR phosphorylation at Tyr-residue in human HN5 cells preincubated for 24 hrs followed by EGF-stimulation and measured aft...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human GST-fused HER2 kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human A431 cell-derived EGFR using polyglutamic acid/tyrosine as substrate incubated for 10 mins followed by [32P]ATP addition and meas...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of B-Raf (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human A431 cell-derived EGFR using Lys-His-Lys-LysLeu-Ala-Glu-Gly-Ser-Ala-Tyr472-Glu-Glu-Val as substrate measured after 10 mins in pre...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of B-Raf (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human GST-fused HER2 kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate measured after 10 minsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 178nMAssay Description:Inhibition of HDAC1 (unknown origin) using HDAC substrate by AFC probe based immunoprecipitation assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 301nMAssay Description:Inhibition of recombinant human His6-tagged HER2 cytoplasmic domain (676 to 1245 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University of South China
Curated by ChEMBL
University of South China
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
