Compile Data Set for Download or QSAR
Found 91 Enz. Inhib. hit(s) with all data for entry = 50008990
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524283(EXEL-7647 | KD-019 | KD-020 | KD019 | Tesevatinib ...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6503(4-Anilino-3-cyanoquinoline deriv. 4 | 6,7-dimethox...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50437353(CHEMBL2408045)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524282(CHEMBL4467033)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50095259((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6511(4-Anilinoquinoline deriv. 8 | 6,7-dimethoxy-N-(3,4...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524281(CHEMBL4440586)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314989(CHEMBL1092250 | N-(3-Ethynylphenyl)-6,7-dimethoxyq...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524281(CHEMBL4440586)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50095259((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524289(CHEMBL535429 | TCMDC-138471)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314989(CHEMBL1092250 | N-(3-Ethynylphenyl)-6,7-dimethoxyq...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)copy SMILEScopy InChI
Affinity DataIC50: 510nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 910nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524286(CHEMBL4447797)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524285(CHEMBL4468521)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524285(CHEMBL4468521)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6503(4-Anilino-3-cyanoquinoline deriv. 4 | 6,7-dimethox...)copy SMILEScopy InChI
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6511(4-Anilinoquinoline deriv. 8 | 6,7-dimethoxy-N-(3,4...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524289(CHEMBL535429 | TCMDC-138471)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524288(CHEMBL4518437)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)copy SMILEScopy InChI
Affinity DataKd:  6.10E+3nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataKd:  0.700nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)copy SMILEScopy InChI
Affinity DataKd:  100nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)copy SMILEScopy InChI
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)copy SMILEScopy InChI
Affinity DataKd:  12nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM185148((3R,4R)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,...)copy SMILEScopy InChI
Affinity DataKd: <225nMAssay Description:Binding affinity to wild-type human partial length TNK2 (S159 to D474 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)copy SMILEScopy InChI
Affinity DataKd:  9.5nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)copy SMILEScopy InChI
Affinity DataKd:  1.10nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
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