Compile Data Set for Download or QSAR
Found 28 Enz. Inhib. hit(s) with all data for entry = 50039936
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate incubated for 10 mi...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386555(CHEMBL2048241)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386558(CHEMBL2048244)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386557(CHEMBL2048243)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386556(CHEMBL2048242)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386552(CHEMBL2048238)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50115104((pyridin-2-ylamino)methylenediphosphonic acid | 2-...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human FPPS using FPP and [3H]-IPP as substrate incubated for 30 mins prior to substrate addition measured after 20 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386550(CHEMBL2048236)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386553(CHEMBL2048239)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386551(CHEMBL2048237)copy SMILEScopy InChI
Affinity DataIC50: 164nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant GGPPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25270([(6E,11E)-2,6,12,16-tetramethyl-9-phosphonoheptade...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386554(CHEMBL2048240)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)copy SMILEScopy InChI
Affinity DataIC50: 475nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 10 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50327500(2-(5-(1H-indazol-5-yl)pyridin-3-yl)-1-fluoroethane...)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386558(CHEMBL2048244)copy SMILEScopy InChI
Affinity DataIC50: 785nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 860nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386555(CHEMBL2048241)copy SMILEScopy InChI
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 m...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386556(CHEMBL2048242)copy SMILEScopy InChI
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM25270([(6E,11E)-2,6,12,16-tetramethyl-9-phosphonoheptade...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386556(CHEMBL2048242)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386558(CHEMBL2048244)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
McGill University

Curated by ChEMBL
LigandPNGBDBM50386555(CHEMBL2048241)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29024V1PubMed