Compile Data Set for Download or QSAR
Found 31 Enz. Inhib. hit(s) with all data for entry = 50046830
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133601(CHEMBL3633251)copy SMILEScopy InChI
Affinity DataKi:  151nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133602(CHEMBL3633250)copy SMILEScopy InChI
Affinity DataKi:  174nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataKi:  316nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133596(CHEMBL3633459)copy SMILEScopy InChI
Affinity DataKi:  347nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133603(CHEMBL3633248)copy SMILEScopy InChI
Affinity DataKi:  372nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133600(CHEMBL3633457)copy SMILEScopy InChI
Affinity DataKi:  501nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133602(CHEMBL3633250)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133604(CHEMBL3633249)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133596(CHEMBL3633459)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133601(CHEMBL3633251)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133603(CHEMBL3633248)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133597(CHEBI:8502 | Propacil | Propylthiouracil | Prothyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMedDrugBank
TargetThyroid peroxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133597(CHEBI:8502 | Propacil | Propylthiouracil | Prothyr...)copy SMILEScopy InChI
Affinity DataIC50: 3.38E+3nMAssay Description:Inhibition of TPO (unknown origin) using Amplex Red as substrate assessed as formation of resorufin measured every 20 secs by spectrophotometric anal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133597(CHEBI:8502 | Propacil | Propylthiouracil | Prothyr...)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+3nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMedDrugBank
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133598(CHEMBL3633458)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+3nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133600(CHEMBL3633457)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2C19 (S)-Mephenytoin 4'-hydroxylase activity in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2C8 amodiaquine-N-deethylase activity in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2B6 bupropion hydroxylase activity in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP1A2 phenacetin O-deethylase activity in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2D6 dextromethorphan O-demethylase activity in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ926XPubMed