Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM200712 (US9233086, 10A) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM200722 (US9233086, 10K) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481602 (CHEMBL5277647) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481601 (CHEMBL5274392) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481600 (CHEMBL5283334) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481599 (CHEMBL5283185) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481598 (CHEMBL5272698) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481597 (CHEMBL5281856) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50481596 (CHEMBL5277870) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM200712 (US9233086, 10A) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470581 (5-Fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azab...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470578 (US10815241, Example 3 | US11369605, Example 3) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470585 (US10815241, Example 10 | US11369605, Example 10) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470582 (US10815241, Example 7 | US11369605, Example 7) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470580 (US10815241, Example 5 | US11369605, Example 5) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM200722 (US9233086, 10K) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM558847 (2-[(4-{7-[(1S,3S,4R,6S)-6-(Cyclopropylmethyl)-2-az...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554135 (US11325921, Example 22) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470584 (US10815241, Example 9 | US11369605, Example 9) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470586 (US10815241, Example 11 | US11369605, Example 11) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470579 (US10815241, Example 4 | US11369605, Example 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM470583 (US10815241, Example 8 | US11369605, Example 8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554134 (US11325921, Example 21) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554136 (US11325921, Example 23) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554133 (US11325921, Example 20) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554059 (US11325921, Example 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554111 (US11325921, Example 2 | US11325921, Example 9) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50601694 (CHEMBL5183439) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00037 BindingDB Entry DOI: 10.7270/Q2B85D61 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554139 (US11325921, Example 26 | US11325921, Example 27) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554116 (US11325921, Example 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554111 (US11325921, Example 2 | US11325921, Example 9) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554112 (US11325921, Example 3) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552984 (4-(difluoromethyl)-N-[4- fluoro-5-(2-morpholin-4- ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552953 (N-[4-fluoro-5-(2- morpholin-4-ylpyrimidin- 5-yl)-2...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552953 (N-[4-fluoro-5-(2- morpholin-4-ylpyrimidin- 5-yl)-2...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554139 (US11325921, Example 26 | US11325921, Example 27) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] (Human-Homo sapiens (Human)) | BDBM525707 (US11174250, Example 125) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q2C53Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554126 (US11325921, Example 11) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 53.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552952 (N-[2-[(3S)-3,4- dimethylpiperazin-1-yl]- 4-fluoro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552981 (N-[5-(2-cyanopyrimidin- 5-yl)-4-fluoro-2-[(3S,5R)-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554138 (US11325921, Example 25) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 90.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552987 (N-[2-[(3R)-3- (dimethylamino)pyrrolidin- 1-yl]-4-f...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552982 (N-[4-fluoro-5-(6- morpholin-4-ylpyridin-3- yl)-2-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554128 (US11325921, Example 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A/Menin (Homo sapiens (Human)) | BDBM554113 (US11325921, Example 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64N9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552989 (N-[5-[6- (cyclopropylmethoxy) pyridin-3-yl]-4-fluo...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50574672 (CHEMBL4861912) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of MLL1 (unknown origin)-mediated H3K4 methylation using histone H3 and SAM as substrate incubated for 30 mins by AlphaScreen assay | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113677 BindingDB Entry DOI: 10.7270/Q2J38XCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL1-WRAD2 complex (Homo sapiens (Human)) | BDBM552978 (N-[4-fluoro-5-(4- morpholin-4-ylphenyl)-2- [(3R,5S...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a... | Citation and Details BindingDB Entry DOI: 10.7270/Q27W6GD6 | |||||||||||
More data for this Ligand-Target Pair |
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