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19 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28252961 13 Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.EBI Goethe-University Frankfurt
27908761 55 Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.EBI Eli Lilly
26985325 62 Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists.EBI Shanghai Institute of Materia Medica
26421921 43 Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.EBI Glenmark Research Centre
26200813 90 Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.EBI Setsunan University
25800431 30 Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid.EBI Ono Pharmaceutical
25408836 44 Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist.EBI Ono Pharmaceutical
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer
20621485 81 Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.EBI Zhejiang University
8709092 21 Modulators of leukotriene biosynthesis and receptor activation.EBI Abbott Laboratories
8496700 16 The Role of Receptor Binding in Drug DiscoveryEBI TBA
 21 Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonistEBI TBA
9871597 65 A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.EBI Merck Frosst Center For Therapeutic Research
3035179 5 High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid.EBI TBA
2170650 4 Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.EBI Merck Frosst Centre For Therapeutic Research
2170649 37 The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency.EBI Rorer Central Research
1372359 3 Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents.EBI Warner-Lambert