The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28252961 |
13 |
Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.![EBI](/images/logo_chembl.png) |
Goethe-University Frankfurt |
27908761 |
55 |
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.![EBI](/images/logo_chembl.png) |
Eli Lilly |
26985325 |
62 |
Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists.![EBI](/images/logo_chembl.png) |
Shanghai Institute of Materia Medica |
26421921 |
43 |
Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.![EBI](/images/logo_chembl.png) |
Glenmark Research Centre |
26200813 |
90 |
Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.![EBI](/images/logo_chembl.png) |
Setsunan University |
25800431 |
30 |
Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid.![EBI](/images/logo_chembl.png) |
Ono Pharmaceutical |
25408836 |
44 |
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist.![EBI](/images/logo_chembl.png) |
Ono Pharmaceutical |
20875743 |
90 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela![EBI](/images/logo_chembl.png) |
Pfizer |
20621485 |
81 |
Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.![EBI](/images/logo_chembl.png) |
Zhejiang University |
8709092 |
21 |
Modulators of leukotriene biosynthesis and receptor activation.![EBI](/images/logo_chembl.png) |
Abbott Laboratories |
8496700 |
16 |
The Role of Receptor Binding in Drug Discovery![EBI](/images/logo_chembl.png) |
TBA |
| 21 |
Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist![EBI](/images/logo_chembl.png) |
TBA |
9871597 |
65 |
A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.![EBI](/images/logo_chembl.png) |
Merck Frosst Center For Therapeutic Research |
3035179 |
5 |
High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid.![EBI](/images/logo_chembl.png) |
TBA |
2170650 |
4 |
Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
2170649 |
37 |
The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency.![EBI](/images/logo_chembl.png) |
Rorer Central Research |
1372359 |
3 |
Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents.![EBI](/images/logo_chembl.png) |
Warner-Lambert |