The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
1527792 |
55 |
Specific inhibition of HIV-1 protease by boronated porphyrins.![EBI](/images/logo_chembl.png) |
University of California |
1635057 |
48 |
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.![EBI](/images/logo_chembl.png) |
Parke-Davis Pharmaceutical Research Division of Warner-Lambert |
3045320 |
37 |
Design of rat renin inhibitory peptides.![EBI](/images/logo_chembl.png) |
Massachusetts General Hospital |
3275777 |
34 |
Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.![EBI](/images/logo_chembl.png) |
Upjohn |
3543358 |
96 |
Pepstatin analogues as novel renin inhibitors.![EBI](/images/logo_chembl.png) |
TBA |
3906131 |
61 |
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.![EBI](/images/logo_chembl.png) |
TBA |
20731374 |
65 |
Direct renin inhibitors as a new therapy for hypertension.![EBI](/images/logo_chembl.png) |
Novartis Pharmaceuticals |
19615901 |
52 |
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.![EBI](/images/logo_chembl.png) |
Nagasaki International University |
| 23 |
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets![EBI](/images/logo_chembl.png) |
TBA |
| 3 |
CP-71,362, an unusually potent inhibitor of rat and dog renin![EBI](/images/logo_chembl.png) |
TBA |
| 1 |
Evaluation of the intestinal permeability and hepatic handling of peptidomimetic analogs![EBI](/images/logo_chembl.png) |
TBA |
| 12 |
MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.![EBI](/images/logo_chembl.png) |
TBA |
15081001 |
17 |
The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template.![EBI](/images/logo_chembl.png) |
Pfizer |
8474102 |
29 |
Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-725![EBI](/images/logo_chembl.png) |
Abbott Laboratories |
8410992 |
35 |
Renin inhibitors containing a pyridyl amino diol derived C-terminus.![EBI](/images/logo_chembl.png) |
Hoechst |
7932521 |
81 |
Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog.![EBI](/images/logo_chembl.png) |
Abbott Laboratories |
3309313 |
48 |
Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.![EBI](/images/logo_chembl.png) |
Abbott Laboratories |
3302256 |
45 |
Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides.![EBI](/images/logo_chembl.png) |
TBA |
3137345 |
19 |
Synthesis and biological activity of some transition-state inhibitors of human renin.![EBI](/images/logo_chembl.png) |
Ciba-Geigy |
3127587 |
33 |
New human renin inhibitors containing an unnatural amino acid, norstatine.![EBI](/images/logo_chembl.png) |
Kissei Pharmaceutical |
2202829 |
18 |
Inhibitors of human renin. Cyclic peptide analogues containing a D-Phe-Lys-D-Trp sequence.![EBI](/images/logo_chembl.png) |
Ici Pharmaceuticals Group |
2197413 |
8 |
Potent renin inhibitory peptides containing hydrophilic end groups.![EBI](/images/logo_chembl.png) |
Upjohn |
29754833 |
73 |
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
1738148 |
16 |
Renin inhibitory pentols showing improved enteral bioavailability.![EBI](/images/logo_chembl.png) |
Hoechst |